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Anti-Heat Shock Protein 40 Rabbit Polyclonal Antibody

Catalog Number: (USBIH1834-15K-100)
Supplier: US Biological
Description: Anti-Heat Shock Protein 40 Rabbit Polyclonal Antibody
UOM: 1 * 100 µl
Image Unavailable-USBIH1832-01C

Anti-Heat Shock Protein 101 Rabbit Polyclonal Antibody

Catalog Number: (USBIH1832-01C)
Supplier: US Biological
Description: Anti-Heat Shock Protein 101 Rabbit Polyclonal Antibody
UOM: 1 * 200 µl
Image Unavailable-USBIT8069-95

Anti-Toxic Shock Syndrome Toxin Rabbit Polyclonal Antibody

Catalog Number: (USBIT8069-95)
Supplier: US Biological
Description: Anti-Toxic Shock Syndrome Toxin Rabbit Polyclonal Antibody
UOM: 1 * 1 mL
Image Unavailable-USBIH1830-48M

Anti-Heat Shock Protein 22 Goat Polyclonal Antibody

Catalog Number: (USBIH1830-48M)
Supplier: US Biological
Description: Anti-Heat Shock Protein 22 Goat Polyclonal Antibody
UOM: 1 * 100 µG
Product Image-USBI041717-HRP

Anti-SHOC2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (USBI041717-HRP)
Supplier: US Biological
Description: Anti-SHOC2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
UOM: 1 * 200 µl
Product Image-BSENC-1700-100

Anti-Heat Shock Protein 27 Chicken Polyclonal Antibody

Catalog Number: (BSENC-1700-100)
Supplier: Biosensis
Description: The heat shock proteins were discovered, as the name suggests, since they are heavily upregulated when cells are stressed by temperatures above the normal physiological range. They are expressed in unstressed cells also and have a normal function as chaperones, helping other proteins to fold correctly, and are required in much greater amounts if the cell or tissue is stressed by heat. The increased levels are generated transcriptionally under the influence of a powerful transcription factor, the heat shock factor 1 (HSF1). The different heat shock proteins were originally named based on their SDS-PAGE mobility, so HSP27 has an apparent molecular weight of 27kDa. It is an abundant protein even under non-stress conditions and frequently shows up as a major spot on 2 dimensional gels of cells or tissues. It is known to associate with a variety of other proteins such as actin, intermediate filament subunits and ubiquitin and is found both in the cytoplasm and the nucleus of cells. HSP27 can become heavily phosphorylated under the influence of multiple protein kinases particularly as a result of activation of the p38/SAPK pathway. Upregulation of this protein is protective against neurodegenerative diseases at least in certain mouse models (1). Point mutations in the HSP27 gene are associated with two neurological diseases, Charcot-Marie-Tooth disease type 2F and distal hereditary motor neuropathy IIB (2). These diseases are associated with axonal loss apparently following defects in the transport of neurofilaments.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7934R-A350

Anti-SHOC2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-7934R-A350)
Supplier: Bioss
Description: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.Involvement in disease:Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) . NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7934R-FITC

Anti-SHOC2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-7934R-FITC)
Supplier: Bioss
Description: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.Involvement in disease:Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) . NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.
UOM: 1 * 100 µl
Image Unavailable-ELTN974270/37

ESD Occupational Shoes, Lace-Up, Enya XXF GTX Low O2 WR CI

Supplier: ELTEN
Description: ESD work shoe made from hydrophobized suede and hydrophobized textile upper and a PU/PU sole (Wellmaxx Flex).

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Product Image-114-9128

ESD safety shoes, BRAYDEN XXTM, strap closure, low, S3

Supplier: ELTEN
Description: Excellent wearer comfort, with a padded upper edge to protect the Achilles’ tendon.

Environmentally Preferable

Product Image-ABEB711033/35

Safety shoes, lace-up, X-Light, 711033/711038

Supplier: Abeba
Description: Anti-static shoe made from smooth leather upper, reflective material, and a lightweight PU sole, resistant to fuels.

Product Image-ELTN729470/45

ESD safety shoes, OWEN, low, S2

Supplier: ELTEN
Description: Excellent wearing comfort, with an ankle-wrapping, softly padded upper edge that provides stability and grip.

Environmentally Preferable

Image Unavailable-ORIGTA306795

Anti-SHOC2 Rabbit Polyclonal Antibody

Catalog Number: (ORIGTA306795)
Supplier: OriGene
Description: Anti-SHOC2 Rabbit Polyclonal Antibody
UOM: 1 * 100 µG
Image Unavailable-KWIN133276540C58

Workwear Shorts, Stretchable, 2543 LWR

Supplier: FRISTADS KANSAS
Description: Lightweight workwear shorts with 4-way stretch panels. Made of water-repellent durable ripstop material with stretch waist and functional pockets.

New Product

Product Image-PRSI5215

Anti-SHOC2 Rabbit Polyclonal Antibody

Catalog Number: (PRSI5215)
Supplier: ProSci Inc.
Description: SHOC2 Antibody: SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.
UOM: 1 * 100 µG
Image Unavailable-LIEB9141004

Accessories for Performance and Perfection Laboratory Freezers with Plastic Inner Liner, SFFsg

Catalog Number: (LIEB9141004)
Supplier: Liebherr
Description: Basket Liebherr short bottom, For: SFFSG 5501
UOM: 1 * 1 items
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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