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Image Unavailable-PERCN9306119

Accessories for chromatographs Clarus® 600 GC/MS

Catalog Number: (PERCN9306119)
Supplier: PerkinElmer
Description: 1/8” brass connectors for click-on traps includes a spring loaded needle valve which seals when trap is removed preventing impurities getting into the system
UOM: 1 * 1 items
Product Image-OMNI00945T-3F

Caps for solvent safety bottles, T-Series

Supplier: OMNIFIT
Description: Outer PP cap, inner PTFE body.

Image Unavailable-BOSSBS-9474R-A750

Anti-NFAT5 Ser1197 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-9474R-A750)
Supplier: Bioss
Description: Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localised to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localisation signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9474R-HRP

Anti-NFAT5 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-9474R-HRP)
Supplier: Bioss
Description: Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9474R-CY3

Anti-NFAT5 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-9474R-CY3)
Supplier: Bioss
Description: Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-15371R-HRP

Anti-GPCR RDC1 Rabbit Polyclonal Antibody (HRP)

Catalog Number: (BOSSBS-15371R-HRP)
Supplier: Bioss
Description: Atypical chemokine receptor that controls chemokine levels and localisation via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalising receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalisation and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
UOM: 1 * 100 µl
Product Image-SCTS1046044

Accessories for self contained breathing apparatus, Cen-Paq

Supplier: SCOTT SAFETY
Description: Steel cylinder, valve fitted with safety locking handwheel, 3,0 litre, 200 bar for total duration of 15 minutes, 5 kg, ∅ 110 mm x length: 375 mm, fully charged, for short duration breathing apparatus Cen-Paq, Cen-Paq

Product Image-216-1305

Accessories for compact canister with screw cap

Catalog Number: (216-1305)
Supplier: BURKLE
Description: Venting valve in screw cap
UOM: 1 * 1 items
Image Unavailable-BOSSBS-9474R-A555

Anti-NFAT5 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-9474R-A555)
Supplier: Bioss
Description: Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.
UOM: 1 * 100 µl
Product Image-MANA730189.12

Accessories for vacuum manifolds, CHROMABOND®

Supplier: MACHEREY-NAGEL
Description: For the CHROMABOND® vacuum manifolds for upto 12, 16 or 24 samples the following accessories are available.

Product Image-UPCHM-140

In-line MicroFilters, Upchurch Scientific®

Supplier: UPCHURCH SCIENTIFIC
Description: These in-line MicroFilters effectively protect columns from particles originating in the mobile phase or sample, or from pump seal and sample injection valve wear.

Product Image-201-0021

Valves, PRODURAN®, DURAN®

Supplier: DWK Life Sciences
Description: DURAN®, borosilicate glass 3.3, clear, with PTFE spindle.

Product Image-LTEALF/LYO/03/0

Accessories for freeze dryers, Lyotrap™ series

Catalog Number: (LTEALF/LYO/03/0)
Supplier: LTE SCIENTIFIC
Description: Accessory for freeze dryer, 8-port flask manifold lid, including 8× 3/4" quickseal valves, For: Lyotrap™ series freeze-dryers
UOM: 1 * 1 items
Image Unavailable-ILMV116264

Welch® Laboratory Vacuum Systems

Catalog Number: (ILMV116264)
Supplier: Welch by Gardner Denver
Description: Chemically resistant diaphragm pump with frequency changer and gas ballast valve. Suction-side separator with 500 ml round-bottomed flask.
UOM: 1 * 1 items
Product Image-ZVGA30931-94

Disposable particle filtering respirators, FFP2/FFP3, Standard Plus-programm, zetMask®

Catalog Number: (ZVGA30931-94)
Supplier: Zellstoff-Vertriebs-GmbH & Co. KG
Description: Ultralight, pre-shaped fine-dust filter masks with exhalation valve for protection against coarse, hazardous particle.
UOM: 1 * 20 items
Product Image-549-0313

Gas-tight syringes, 10 to 500 µl

Supplier: Trajan Scientific and Medical
Description: Constructed from borosilicate glass, PTFE plunger tips and Kel-F® or PTFE Luer cones where applicable.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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