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Product Image-392-0407

VWR®, Cell culture media, Dulbecco's Modified Eagles Medium (DMEM)

Supplier: VWR Chemicals
Description: Dulbecco's Modified Eagle Medium (DMEM) is designed to preserve and maintain the growth of a broad spectrum of mammalian cell types.

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Product Image-392-0406

VWR®, Penicillin-streptomycin solution (100X)

Catalog Number: (392-0406)
Supplier: VWR Chemicals
Description: VWR® penicillin-streptomycin solution (100X) is a large spectrum antibiotic designed to control and destroy gram-negative and gram-positive bacteria.
UOM: 1 * 100 mL

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Product Image-1B1558-KIT

VWR® Fluorescent DNA Quantitation Kit

Catalog Number: (1B1558-KIT)
Supplier: VWR Chemicals
Description: Fluorescent DNA Quantitation Kit uses fluorescent bisBenzimide H33258 dye to bind to AT sequences of the minor groove of double-stranded DNA. In the assay, the sample is excited at 360 nm and when the dye binds to dsDNA an emission spectrum at 460 nm is produced.
UOM: 1 * 1 KIT
Image Unavailable-CAYM21046-100

Sisomicin ≥98%

Supplier: Cayman Chemical
Description: Sisomicin is a broad-spectrum aminoglycoside antibiotic originally isolated from M. inyoensis.

Product Image-1.04907.0500

Potassium bromide, Uvasol® for IR spectrophotometry, Supelco®

Supplier: Merck
Description: Potassium bromide is transparent from the near UV to long wave IR wavelengths. In IR-spectroscopy, solid samples which are difficult to melt or dissolve in any suitable IR-transmitting solvent, are analysed by grinding with potassium bromide powder, and pressing into a disc. This procedure has a high quality demand of the used potassium bromide. Potassium bromide Uvasol® is adjusted to a mean particle size of 150 μm. This is sufficient for the preparation of perfectly good pellets without the need for further pre-treatment and the associated risk of contamination. It also retains its powdery form over a period of years if stored in an airtight condition. Its physical suitability for pelletising is checked by a special application test and its chemical purity established by full spectrum FT-IR analysis.

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Product Image-SPEC148862

Mesh woven filters, PEEK, Spectra Mesh®

Supplier: Spectrum Laboratories
Description: These woven filters are constructed of individual strands woven into a mesh screen, characterised by precise mesh openings, percent open area and mesh thickness. Available in five material types with different physical, chemical and thermal characteristics to select from depending on your application. Available in discs or square sheets.

Image Unavailable-CAYM15260-5

Q-VD-OPh

Supplier: Cayman Chemical
Description: Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 µm. It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK and Boc-D-FMK.

Image Unavailable-CAYM10009222-10

SKI-II ≥95%, crystalline solid

Supplier: Cayman Chemical
Description: Sphingosine kinase isoforms, SPHK 1 and SPHK 2, catalyse the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. Sphingosine kinase inhibitor 2 (SPHK I<sub>2</sub>) is a potent, selective inhibitor of SPHK 1 with anti-proliferative activity.

Product Image-SPEC145908

Mesh woven filters, nylon, Spectra Mesh®

Supplier: Spectrum Laboratories
Description: These woven filters are constructed of individual strands woven into a mesh screen, characterised by precise mesh openings, percent open area and mesh thickness. Available in five material types with different physical, chemical and thermal characteristics to select from depending on your application. Available in discs or square sheets.

Product Image-SPEC146422

Mesh woven filters, PP, Spectra Mesh®

Supplier: Spectrum Laboratories
Description: These woven filters are constructed of individual strands woven into a mesh screen, characterised by precise mesh openings, percent open area and mesh thickness. Available in five material types with different physical, chemical and thermal characteristics to select from depending on your application. Available in discs or square sheets.

Product Image-SPEC145827

Mesh woven filters, stainless steel, Spectra Mesh®

Supplier: Spectrum Laboratories
Description: These woven filters are constructed of individual strands woven into a mesh screen, characterised by precise mesh openings, percent open area and mesh thickness. Available in five material types with different physical, chemical and thermal characteristics to select from depending on your application. Available in discs or square sheets.

Product Image-734-3561

Mesh woven filters, polyester, Spectra Mesh®

Supplier: Spectrum Laboratories
Description: These woven filters are constructed of individual strands woven into a mesh screen, characterised by precise mesh openings, percent open area and mesh thickness. Available in five material types with different physical, chemical and thermal characteristics to select from depending on your application. Available in discs or square sheets.

Product Image-514-0639

Dialysis membrane tubing, Biotech RC

Supplier: Spectrum Laboratories
Description: Biotech RC (Regenerated Cellulose) dialysis tubing is crafted from a regeneration process that yields superior temperature tolerances and chemical compatibilities with the same high purity and selectivity as Biotech CE. RC membrane can tolerate concentrated-weak acids & bases, dilute-strong acids and bases, most alcohols and some mild or dilute organic solvents. Exposure to strong polar or organic solvents may damage RC membranes. Use with pH 2 - 12 and temperature 4 - 60 °C.

Image Unavailable-BOSSBS-15482R-CY7

Anti-hHR23b Rabbit Polyclonal Antibody (Cy7)

Catalog Number: (BOSSBS-15482R-CY7)
Supplier: Bioss
Description: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-15482R-A647

Anti-hHR23b Rabbit Polyclonal Antibody (ALEXA FLUOR® 647)

Catalog Number: (BOSSBS-15482R-A647)
Supplier: Bioss
Description: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-15482R-CY5

Anti-hHR23b Rabbit Polyclonal Antibody (Cy5)

Catalog Number: (BOSSBS-15482R-CY5)
Supplier: Bioss
Description: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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