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Product Image-BSENS-077-100

Anti-beta synuclein Sheep Polyclonal Antibody

Catalog Number: (BSENS-077-100)
Supplier: Biosensis
Description: Beta-synuclein is a non-amyloid component of senile plaques found in Alzheimer disease. It could act as a regulator of SNCA aggregation. It protects neurons from staurosporine and 6 hydroxy dopamine -stimulated capspase activation in a p53-dependent manner. It localises to the cytoplasm and it is predominantly expressed in the brain where it is most concentrated in presynaptic nerve terminals. This protein is phosphorylated. This protein is also associated with the disease Brain iron accumulation type 1 (NBIA1).
UOM: 1 * 100 µG
Image Unavailable-BOSSBS-0738R-CY3

Anti-BIRC7 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-0738R-CY3)
Supplier: Bioss
Description: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0738R-CY5.5

Anti-BIRC7 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (BOSSBS-0738R-CY5.5)
Supplier: Bioss
Description: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0738R-A350

Anti-BIRC7 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-0738R-A350)
Supplier: Bioss
Description: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
UOM: 1 * 100 µl
Image Unavailable-00025.

Staurosporine

Catalog Number: (00025.)
Supplier: Biotium
Description: Staurosporine is a potent apoptosis inducer.
UOM: 1 * 100 µG
Image Unavailable-ICNA0219140080

Staurosporine ≥98%

Supplier: MP Biomedicals
Description: Staurosporine is provided in a lyophilised form. It may be reconstituted by dissolving the lyophilised reagent in DMSO (5 mg/ml - clear, colourless solution), DMF, ethyl acetate (5 mg/ml - clear colourless solution) or methanol. Stock solutions should be further diluted with aqueous buffers just prior to use. Stability depends upon the quality of solvent used. The compound should be stored at −20 °C in the dark.

Product Image-AATB80050

Staurosporine 1 mM, ReadiUse™ for apoptosis positive control

Catalog Number: (AATB80050)
Supplier: AAT BIOQUEST
Description: Staurosporine is widely used as a positive control for inducing apoptosis.
UOM: 1 * 100 µl
Image Unavailable-J62837.MA

Staurosporine ≥99%

Catalog Number: (J62837.MA)
Supplier: Thermo Fisher Scientific
Description: Staurosporine ≥99%
UOM: 1 * 10 mg

MSDS Certificates


Image Unavailable-569396-100

Staurosporine (from Streptomyces species), InSolution™, Millipore®

Catalog Number: (569396-100)
Supplier: Merck Millipore (Calbiochem‎)
Description: InSolution™ Staurosporine, <i>Streptomyces sp</i>. is provided as a 1 mM (100 µg/214 µl) solution of Staurosporine in DMSO.
UOM: 1 * 100 µG
Image Unavailable-HONCR1061-10MG

Analytical standard, Staurosporine, reference material, Honeywell Fluka™

Catalog Number: (HONCR1061-10MG)
Supplier: Honeywell Chemicals
Description: Organic Standard, Staurosporine, Pack type: Glass Bottle
UOM: 1 * 10 mg
Image Unavailable-ENZOBMLEI3700005

Midostaurin ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES
Description: Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.

New Product

Product Image-PRSI55-786

Anti-CARD16 Rabbit Polyclonal Antibody

Catalog Number: (PRSI55-786)
Supplier: ProSci Inc.
Description: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
UOM: 1 * 400 µl

New Product


Image Unavailable-ABCAAB146588-100

STAUROSPORINE (DMSO SOLUTION) 1 * 100 µG

Catalog Number: (ABCAAB146588-100)
Supplier: Abcam
Description: STAUROSPORINE (DMSO SOLUTION) 1 * 100 µG
UOM: 1 * 100 µG
Image Unavailable-CAYM81590-1

STAUROSPORINE 1 * 1 mg

Catalog Number: (CAYM81590-1)
Supplier: Cayman Chemical
Description: STAUROSPORINE 1 * 1 mg
UOM: 1 * 1 mg
Image Unavailable-APOSBIS0504-50MG

Staurosporine, from Streptomyces sp. 50mg pack 1 * 50 mg

Catalog Number: (APOSBIS0504-50MG)
Supplier: Apollo Scientific
Description: Staurosporine, from Streptomyces sp. 50mg pack 1 * 50 mg
UOM: 1 * 50 mg

New Product


Image Unavailable-ABCAAB136806-2

HELA APOPTOSIS LYSATE SET: STAUROSPORINE 1 * 2 AU

Catalog Number: (ABCAAB136806-2)
Supplier: Abcam
Description: HELA APOPTOSIS LYSATE SET: STAUROSPORINE 1 * 2 AU
UOM: 1 * 2 AU
Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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