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Product Image-ENZOALX270256G001

Clofibrate ≥98% (by GC)

Catalog Number: (ENZOALX270256G001)
Supplier: ENZO LIFE SCIENCES
Description: PPARα activator.
UOM: 1 * 1 g
Product Image-ACRO462260250

Valacyclovir hydrochloride hydrate

Supplier: Thermo Fisher Scientific
Description: Valacyclovir hydrochloride hydrate

Product Image-ACRO269920025

Bis(2-ethylhexyl)sebacate 97%

Supplier: Thermo Fisher Scientific
Description: Bis(2-ethylhexyl)sebacate 97%

MSDS

Image Unavailable-PROOMM0499.00

Tributyl acetylcitrate

Catalog Number: (PROOMM0499.00)
Supplier: LGC Standards PROMOCHEM
Description: Tributyl acetylcitrate
UOM: 1 * 500 mg
Image Unavailable-APOSPC408427-25G

Ethyl 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 95+%

Catalog Number: (APOSPC408427-25G)
Supplier: Apollo Scientific
Description: Ethyl 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 95+%
UOM: 1 * 25 g
Image Unavailable-A16049.AK

Bis(2-ethylhexyl)sebacate 95%

Supplier: Thermo Fisher Scientific
Description: Bis(2-ethylhexyl)sebacate 95%

MSDS Certificates

Image Unavailable-APOSBISN0117-10MG

TAK-242

Supplier: Apollo Scientific
Description: TAK-242, a small-molecule-specific inhibitor of Toll-like receptor (TLR)4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4.

Image Unavailable-APOSOR30732-100MG

tert-Butyl-5-amino-1H-indazole-1-carboxylate

Catalog Number: (APOSOR30732-100MG)
Supplier: Apollo Scientific
Description: tert-Butyl-5-amino-1H-indazole-1-carboxylate
UOM: 1 * 100 mg
Product Image-ACRO459370250

Mycophenolate mofetil 98%

Supplier: Thermo Fisher Scientific
Description: Mycophenolate mofetil 98%

Image Unavailable-APOSBISN0166-1MG

NQDI-1

Catalog Number: (APOSBISN0166-1MG)
Supplier: Apollo Scientific
Description: MAPK/ERK Signalling Pathway
UOM: 1 * 1 mg
Image Unavailable-CAYM14270-500

Rivastigmine-L-tartrate ≥95%, crystalline solid

Supplier: Cayman Chemical
Description: Rivastigmine is an irreversible inhibitor of acetylcholinesterase (IC<sub>50</sub>=4,15 µm) and butyrylcholinesterase (IC<sub>50</sub>=37 nM).

Image Unavailable-BOSSBS-5251R-CY7

Anti-CHEK1 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-5251R-CY7)
Supplier: Bioss
Description: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5251R-A555

Anti-CHEK1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-5251R-A555)
Supplier: Bioss
Description: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5251R-A350

Anti-CHEK1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-5251R-A350)
Supplier: Bioss
Description: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA.
UOM: 1 * 100 µl
Image Unavailable-329600-5

Erastin ≥98% (by HPLC), solid, Calbiochem®, Sigma-Aldrich®

Catalog Number: (329600-5)
Supplier: Merck Millipore (Calbiochem‎)
Description: Antitumor agent
UOM: 1 * 5 mg
Image Unavailable-H33319.03

2-Amino-3,3,3-trifluoropropionic acid ethylester hydrochloride 96%

Catalog Number: (H33319.03)
Supplier: Thermo Fisher Scientific
Description: 2-Amino-3,3,3-trifluoropropionic acid ethylester hydrochloride 96%
UOM: 1 * 1 g

MSDS


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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