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Catalog Number: (BOSSBS-11539R)
Supplier: Bioss
Description: The Rac-GAP chimaerin family member Alpha-chimaerin (also known as N-chimaerin or rho GTPase-activating protein 2) has two splice variants: Alpha1 and Alpha2. The ?-chimaerin variant is a neuron-specific, diacylglycerol-binding and GTPase-activating protein for ras-related protein Rac 1. This variant lacks the N-terminal SH2 domain that is present in the Alpha2 variant. By inactivating Rac 1, Alpha1-chimaerin plays a significant role in the regulation of dendritic growth during neuronal development. It is recruited to the plasma membrane by phospholipase C Beta-coupled cell surface receptors activating the downstream generation of DAG (diacylglycerol). Overexpression of Alpha1-chimaerin results in dendritic spine retraction and the loss of dendritic branches. In the presence of reduced neuronal activity, Alpha1-chimaerin expression is down-regulated resulting in an increase in spine growth and dendritic branching.
UOM: 1 * 100 µl


Catalog Number: (USBI033856)
Supplier: US Biological
Description: Anti-CHN1 Rabbit Polyclonal Antibody
UOM: 1 * 200 µl


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Catalog Number: (USBI033858)
Supplier: US Biological
Description: Anti-CHN2 Rabbit Polyclonal Antibody
UOM: 1 * 200 µl


Catalog Number: (USBI033858-BIOTIN)
Supplier: US Biological
Description: Anti-CHN2 Rabbit Polyclonal Antibody (Biotin)
UOM: 1 * 200 µl


Catalog Number: (ANTIA82874-100)
Supplier: ANTIBODIES.COM
Description: Goat polyclonal antibody to CHN2 for ELISA and IHC with samples derived from human.
UOM: 1 * 100 µG

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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