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Description: Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of cyclosporin A (CsA) and is encoded by a single unique gene conserved from yeast to humans. Cyclophilin B (CyPB) is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes. Cyclophilin D (CyP40) is a widely expressed cytoplasmic protein that catalyses the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. It is a widely expressed cytoplasmic protein.
Catalog Number: BOSSBS-9878R-A750
UOM: 1 * 100 µl
Supplier: Bioss


Description: Retinoids are metabolites of vitamin A (retinal) and are believed to represent important signaling molecules during vertebrate development and tissue differentiation. Two families of retinoid receptors have been identified. Retinoic acid receptors (RARs) include RAR alpha, RAR beta and RAR gamma, each of which has a high affinity for all trans retinoic acids and belongs to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. The ligand binding domains of the RARs are highly conserved and RAR isoforms are expressed in distinct patterns through out development and in the mature organism. Members of the retinoid X receptor (RXR) family, RXR alpha, RXR beta and RXR gamma, are activated by 9 cis retinoic acid, a stereo and photoisomer of all trans RA that is expressed in vivo in both liver and kidney and may represent a widely used hormone.
Catalog Number: BOSSBS-2802R-A680
UOM: 1 * 100 µl
Supplier: Bioss


Description: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
Catalog Number: BOSSBS-7953R-A680
UOM: 1 * 100 µl
Supplier: Bioss


Description: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
Catalog Number: BOSSBS-0516R-CY7
UOM: 1 * 100 µl
Supplier: Bioss


Description: Retinoids are metabolites of vitamin A (retinal) and are believed to represent important signaling molecules during vertebrate development and tissue differentiation. Two families of retinoid receptors have been identified. Retinoic acid receptors (RARs) include RAR alpha, RAR beta and RAR gamma, each of which has a high affinity for all trans retinoic acids and belongs to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. The ligand binding domains of the RARs are highly conserved and RAR isoforms are expressed in distinct patterns through out development and in the mature organism. Members of the retinoid X receptor (RXR) family, RXR alpha, RXR beta and RXR gamma, are activated by 9 cis retinoic acid, a stereo and photoisomer of all trans RA that is expressed in vivo in both liver and kidney and may represent a widely used hormone.
Catalog Number: BOSSBS-2802R-A647
UOM: 1 * 100 µl
Supplier: Bioss


Description: (2,4-Dioxothiazolidin-5-yl)acetic acid
Catalog Number: APOSOR300906-250MG
UOM: 1 * 250 mg
Supplier: Apollo Scientific


Description: 3-(2,4-Dimethoxyphenyl)propionic acid 97%
Catalog Number: APOSOR452066-25G
UOM: 1 * 25 g
Supplier: Apollo Scientific


Description: 5-Bromo-2,4-difluorobenzeneboronic acid 98%
Catalog Number: APOSPC53563-5G
UOM: 1 * 5 g
Supplier: Apollo Scientific


Description: 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 97%
Catalog Number: APOSOR9929-250MG
UOM: 1 * 250 mg
Supplier: Apollo Scientific


Description: (2,4-difluoro-3-methylphenyl)boronic acid 98%
Catalog Number: APOSPC900770-1G
UOM: 1 * 1 g
Supplier: Apollo Scientific


Description: 2,4-Difluoro-3-(trifluoromethoxy)benzeneboronic acid
Catalog Number: APOSPC57484-1G
UOM: 1 * 1 g
Supplier: Apollo Scientific


Description: (2,4-Dichlorophenoxy)acetic acid hydrazide
Catalog Number: APOSOR11078-25G
UOM: 1 * 25 g
Supplier: Apollo Scientific


Description: 2,4-Dichloro-5-methoxyphenylboronic acid 98%
Catalog Number: APOSOR361110-1G
UOM: 1 * 1 g
Supplier: Apollo Scientific


Description: 2,4-difluoro-3-hydroxybenzoic acid 95%
Catalog Number: APOSPC901612-250MG
UOM: 1 * 250 mg
Supplier: Apollo Scientific


Description: 2,4-Difluoro-5-methylphenylacetic acid 98%
Catalog Number: APOSPC303305-1G
UOM: 1 * 1 g
Supplier: Apollo Scientific


Description: 2,4-Difluoro-3-(trifluoromethoxy)benzoic acid
Catalog Number: APOSPC502108-250MG
UOM: 1 * 250 mg
Supplier: Apollo Scientific


481 - 496 of 123 013