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Catalog Number: (OXOISR0098E)

Supplier: THERMO FISHER DIAGNOSTICS GMBH

Description: Campylobacter supplement (Blaser Wang), Application: Campylobacter, Freeze-dried

UOM: 1 * 10 Vial

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Supplier: VARIAN

Description: PL-Wang is a 4-alkoxybenzylalcohol functionalised polystyrene, prepared from copolymerised PL-CMS, for solid phase peptide synthesis using Fmoc protection strategies and is cleaved using ~ 95% TFA. Particularly useful for solid phase synthesis of small molecules which have a carboxylic acid functional group.

Catalog Number: (PIER20665)

Supplier: Thermo Fisher Scientific

Description: Thermo Scientific Pierce DTBP is dimethyl 3,3'-dithiobispropionimidate, a crosslinker that contains amine-reactive imidoester groups around an 8-atom spacer arm, whose central disulfide bond can be cleaved with reducing agents.

UOM: 1 * 1 g

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Catalog Number: (PRSI25-104)

Supplier: ProSci Inc.

Description: EBF4 belongs to the COE family and contains 1 IPT/TIG domain. EBF4 is a transcriptional factor which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. EBF4 belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors, members of which play important roles in neural development and B-cell maturation (Wang et al., 2002 [PubMed 12139918]).

UOM: 1 * 50 µG

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Catalog Number: (PRSI25-851)

Supplier: ProSci Inc.

Description: TRIM45 is a member of the tripartite motif family. It may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described. TRIM45 belongs to a family of tripartite motif (TRIM) proteins that play important roles in a variety of cellular functions, including cell proliferation, differentiation, development, oncogenesis, and apoptosis (Wang et al., 2004 [PubMed 15351693]).

UOM: 1 * 50 µG

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Catalog Number: (PRSI25-852)

Supplier: ProSci Inc.

Description: TRIM45 is a member of the tripartite motif family. It may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.TRIM45 belongs to a family of tripartite motif (TRIM) proteins that play important roles in a variety of cellular functions, including cell proliferation, differentiation, development, oncogenesis, and apoptosis (Wang et al., 2004 [PubMed 15351693]).

UOM: 1 * 50 µG

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Supplier: STEMCELL Technologies

Description: Insulin-like growth factor 1 (IGF-I) is a polypeptide which belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway; it also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang <i>et al.</i>). Together with interleukin 3 (IL-3), IGF-I stimulates differentiation and proliferation of myeloid cells, and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk <i>et al.</i>).

Supplier: STEMCELL Technologies

Description: Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang <i>et al.</i>). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk <i>et al.</i>). This product is animal component-free.

Supplier: STEMCELL Technologies

Description: Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang <i>et al.</i>). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk <i>et al.</i>).

Catalog Number: (PRSI56-815)

Supplier: ProSci Inc.

Description: Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).

UOM: 1 * 400 µl

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Catalog Number: (STMC100-1404)

Supplier: STEMCELL Technologies

Description: Stimulating T cells with HHV8 (K8.1) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HHV8 (K8.1) Peptide pool is a lyophilised mixture of 55 peptides from glycoprotein K8.1 of human herpesvirus 8 (HHV-8) and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 228 on K8.1. Expressed in the late-lytic phase, K8.1 is a viral envelope protein that binds to heparin sulfate on the cell surface and facilitates HHV 8 infection (Zoeteweij et al; Birkmann <i>et al.</i>; Wang <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

UOM: 1 * 1 AU

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Catalog Number: (STMC100-0937)

Supplier: STEMCELL Technologies

Description: gAdiponectin, also known as an adipocyte component-related protein of 30 kDa, is a member of defense collagens, and its structure is similar to C1q-a member of the complement-related family of proteins (Chandran <i>et al.</i>). gAdiponectin is expressed by differentiated adipocytes and it is composed of three defined domains: N-terminus-containing hypervariable region, collagenous stalk containing 22 GXY repeats, followed by a C-terminus globular domain (Wang <i>et al.</i>). gAdiponectin has also been identified as a hematopoietic stem cell growth factor (DiMascio <i>et al.</i>), and is known to regulate bone marrow mesenchymal stem cell niche (Yu <i>et al.</i>). The globular domain of adiponectin (gAcrp30) has been shown to significantly reduce plasma-free fatty acids and glucose levels in mice (Wong <i>et al.</i>), and to regulate glucose and fatty acid uptake and oxidation in cardiomyocytes (Palanivel <i>et al.</i>). This product is animal component-free.

UOM: 1 * 100 µG

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Supplier: STEMCELL Technologies

Description: Fibroblast growth factor 16 (FGF-16) is a heparin-binding member of the FGF family. FGFs possess broad mitogenic and cell survival activities and are expressed during embryonic development. FGFs act primarily on cells of mesodermal and neuroectodermal origin to regulate diverse physiological functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, and tissue repair (Goldfarb; Green <i>et al.</i>). In vitro, FGF-16 has been shown to promote the proliferation of brown adipocytes and in rat embryos it is predominantly expressed in these cells. FGF-16 has also been shown to play a critical role in embryonic heart development and is thought to play a cardioprotective role after birth (Hotta <i>et al.</i>; Lu <i>et al.</i>; Wang <i>et al.</i>).

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Catalog Number: (STMC100-1403)

Supplier: STEMCELL Technologies

Description: Stimulating T cells with HHV8 (K8) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HHV8 (K8) peptide pool is a lyophilised mixture of 57 peptides from protein K8 alpha of human herpesvirus 8 (HHV-8), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 237 on K8. A basic leucine zipper (bZip) protein that associates with the lytic origin of HHV8 (Lin <i>et al.</i>), K8 is thought to play a role in lytic DNA replication, as a trans-acting factor (AuCoin <i>et al.</i>). It has also been found to modulate the activity of the transcriptional transactivator K-Rta (Izumiya <i>et al.</i>), and has an autoregulatory function (Wang <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

UOM: 1 * 1 AU

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Supplier: STEMCELL Technologies

Description: Heregulin-beta 1 also known as neuregulin-1 (NRG-1) is a member of the epidermal growth factor (EGF) family of growth factors and acts as a ligand for ErbB family receptor tyrosine kinases (Britsch <i>et al.</i>). Heregulin/neuregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3, and NRG4). Heregulin-beta 1 plays an important role during the development of the nervous system, heart, and mammary glands (Britsch). Heregulin-beta 1 is expressed in neuronal cells, and modulates cell growth and differentiation of the cells during development and wound healing (Mei and Xiong). It has been implicated through in vivo and in vitro studies that heregulin-beta 1/ErbB signaling is crucial for multiple aspects of cardiovascular development and protects the heart from ischemic injury (Odiete <i>et al.</i>). Heregulin-beta 1 also promotes invasiveness and metastasis of breast cancer cells (Hutcheson <i>et al.</i>). It has also been shown that heregulin-beta 1 has a role in the growth and maintenance of human embryonic stem cells (Wang <i>et al.</i>).

Catalog Number: (STMC100-1326)

Supplier: STEMCELL Technologies

Description: Commonly known as vaspin, Serpin A12 is an adipokine that is thought to perform insulin-sensitizing functions, such as the regulation of kallikrein 7 (KLK7), an insulin-inhibiting protease (Heiker <i>et al.</i>). The Serpin A12 glycoprotein belongs to the serine protease inhibitor family (serpin), and is mainly associated with obesity, insulin resistance, and glucose metabolism, but may also protect against high fat-induced bone loss (Wang <i>et al.</i>). Serpins share a highly conserved core structure with multiple α-helices, β-strands, and a reactive site loop (RCL) to interact with the target protease (Huntington). It is expressed predominantly in visceral adipose tissue and at significantly higher amounts in obese individuals (Kurowska <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, Serpin A12 from STEMCELL comes lyophilised with ≥94% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.

UOM: 1 * 100 µG

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