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Supplier: ENZO LIFE SCIENCES
Description: The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

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Supplier: ENZO LIFE SCIENCES
Description: The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

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Supplier: ENZO LIFE SCIENCES
Description: Retinoid X receptor ligand.

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Catalog Number: (ENZOBMLG4100001)
Supplier: ENZO LIFE SCIENCES
Description: Mast cell degranulating peptide.
UOM: 1 * 1 mg

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Catalog Number: (ENZOBMLG4210001)
Supplier: ENZO LIFE SCIENCES
Description: Inactive mastoparan analog.
UOM: 1 * 1 mg

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Catalog Number: (ENZOBMLG4150001)
Supplier: ENZO LIFE SCIENCES
Description: Mast cell degranulating peptide.
UOM: 1 * 1 mg

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Catalog Number: (ENZOBMLG2450005)
Supplier: ENZO LIFE SCIENCES
Description: Active carboxylate form of Lovastatin. Active in whole cells as well as cell-free assays. Inhibits cholesterol/ isoprenoid biosynthesis by inhibition of HMG-CoA reductase (Ki for acid form is 1 nM) and blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Causes cells to arrest early in the G1 phase.
UOM: 1 * 5 mg

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Catalog Number: (ENZOBMLGR1020500)
Supplier: ENZO LIFE SCIENCES
Description: Retinoic acid receptor ligand.
UOM: 1 * 500 mg

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Supplier: ENZO LIFE SCIENCES
Description: Hsp60 is a member of the chaperonin family of heat shock proteins, with homologs functioning in the cytosol and mitochondria to fold nascent and aggregated proteins. Hsp60 is the eukaryotic homolog of the E. coli GroEL protein, and forms a multimeric complex in the mitochondria with Hsp10 (Cpn10) to form a large central cavity in which ATP-dependent protein folding takes place. TRiC/CCT, a eukaryotic relative of Hsp60, is expressed in the cytosol and participates in the folding of actin and tubulin substrates, but lacks any association with an Hsp10-like co-factor.

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Supplier: ENZO LIFE SCIENCES
Description: Guanylyl cyclase activator

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Catalog Number: (ENZOALX400001G005)
Supplier: ENZO LIFE SCIENCES
Description: Sodium nitroprusside dihydrate
UOM: 1 * 5 g

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Catalog Number: (ENZOALX385034M100)
Supplier: ENZO LIFE SCIENCES
Description: CYP1A1 inhibitor
UOM: 1 * 100 mg

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Catalog Number: (ENZOALX400009M025)
Supplier: ENZO LIFE SCIENCES
Description: Nitric oxide donor.
UOM: 1 * 25 mg

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Catalog Number: (ENZOALX420029M005)
Supplier: ENZO LIFE SCIENCES
Description: PPARγ agonist.
UOM: 1 * 5 mg

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Catalog Number: (ENZOALX400048G010)
Supplier: ENZO LIFE SCIENCES
Description: Busulfan is antineoplastic bifunctional, DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins.
UOM: 1 * 10 g

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Catalog Number: (ENZOENZ53004C100)
Supplier: ENZO LIFE SCIENCES
Description: Nucleus dye
UOM: 1 * 100 µl

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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