You Searched For: ENZO LIFE SCIENCES

Catalog Number: (ENZOALX380011M050)

Supplier: ENZO LIFE SCIENCES

Description: Antibiotic which suppresses nitric oxide (NO) toxicity in pancreatic islet cells. Inhibits protein synthesis by inhibition of elongation factor G at the level of the ribosome.

UOM: 1 * 50 mg

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Supplier: ENZO LIFE SCIENCES

Description: Immunosuppressant.

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Catalog Number: (ENZOALX350417M001)

Supplier: ENZO LIFE SCIENCES

Description: Phomopsin A ≥98% (by HPLC)

UOM: 1 * 1 mg

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Catalog Number: (ENZOALX350411M005)

Supplier: ENZO LIFE SCIENCES

Description: Triterpenoid. Antitumor agent. Induces caspase-dependent apoptosis by inhibiting the chymotrypsin-like activity of the proteasome. Inhibits NF-κB activation via inhibition of IKKα or IKKβ. Inhibits induction of inducible nitric oxide synthase (iNOS; NOS II). Shows in vitro antimalarial and insecticidal activity. Induces mitochondrial cell death. Has antiproliferative, antifungal and antiviral properties. Potent and reversible monoacylglycerol lipase (MGL) inhibitor.

UOM: 1 * 5 mg

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Catalog Number: (ENZOALX370009M005)

Supplier: ENZO LIFE SCIENCES

Description: PKC activator.

UOM: 1 * 5 mg

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Catalog Number: (ENZOADI905756100)

Supplier: ENZO LIFE SCIENCES

Description: Stats (Signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, Stats enter the nucleus to regulate transcription of many different genes.

UOM: 1 * 100 µG

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Catalog Number: (ENZOADI905769100)

Supplier: ENZO LIFE SCIENCES

Description: Lysine-specific demethylase 1 (LSD1, AOF2, BHC110) is a nuclear amine oxidase homolog, and was the first such protein to display definitive activity in epigenetic modulation as a histone demethylase. LSD1 demethylates histone H3 at mono- or di-methylated lysine residues. Depending on associated co-factors, LSD1-mediated demethylation can lead to transcriptional repression or activation.

UOM: 1 * 100 µG

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Catalog Number: (ENZOADI905782100)

Supplier: ENZO LIFE SCIENCES

Description: Synaptophysin is an integral membrane protein involved in neurotransmitter exocytosis. This protein consists of four transmembrane domains, with its N- and C-terminus facing the cytoplasm. Studies have shown Synaptophysin to be a major cholesterol-binding protein in brain synaptic vesicles.

UOM: 1 * 100 µG

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Catalog Number: (ENZOADI905678100)

Supplier: ENZO LIFE SCIENCES

Description: Src is a member of the tyrosine kinase family that was originally identified as the oncogene of Rous sarcoma virus. The catalytic domain contains a tyrosine autophosphorylation site that increases kinase activity when phosphorylated. The Src family of tyrosine kinase is involved in a variety of receptor-induced signal transduction pathways such as immune recognition rec

UOM: 1 * 100 µG

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Catalog Number: (ENZOADI905790100)

Supplier: ENZO LIFE SCIENCES

Description: Endothelins are vasoactive peptides that exist in three forms (ET-1, ET-2, and ET-3), and function in the maintenance of vascular tone via two identified seven transmembrane-spanning domain-containing G protein-coupled receptors (GPCR), endothelin A (ETA) and endothelin B (ETB). The human ETA receptor is primarily expressed in vascular smooth muscle cells, including those of the heart (also in myocytes), lung, and brain, and its stimulation generally results in vasoconstriction. Activation of ETA receptors can be stimulated by binding of ET-1 and ET-2, but not ET-3. triggering the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells. Human ETB receptors are primarily expressed in endothelial cells lining the vessel walls of the lungs, heart, and brain, and in contrast to ETA receptors, stimulation generally results in transient vasodilation. Activation of ETB receptors can be stimulated by binding of all three endothelins, triggering the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells. Both ETA and ETB receptors signal primarily via coupling to Gq/11 alpha subunits, although Gi/o and Gs coupling are also established mechanisms of endothelin signaling, resulting in stimulation of phospholipases C, A2, and D.

UOM: 1 * 100 µG

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Catalog Number: (ENZOADI905793100)

Supplier: ENZO LIFE SCIENCES

Description: Leukotrienes are metabolic products of arachidonic acid formed by the action of 5-lipoxygenase (5-LO), with the principal products being leukotrienes C4 (LTC4) and B4 (LTB4). LTB4 is a dihydroxy-leukotriene produced in a variety of cells including eosinophils, neutrophils, platelets, and vascular cells, and is a potent leukocyte chemoattractant known to regulate leukocyte activation, cytokine secretion, inflammatory gene transcription, and IgE synthesis. As such, LTB4 has been implicated in a number of disease pathologies including atherosclerosis, asthma, psoriasis, and inflammatory bowel disease. The many actions of LTB4 are associated with two identified mammalian receptors, BLT1 and BLT2. BLT1 is a high-affinity LTB4 receptor expressed on peripheral leukocytes, while BLT2 is a more ubiquitously expressed low affinity LTB4 receptor whose function is not well understood. The BLT1 receptor is transiently expressed by antigen-primed T-cells in humans, and its expression is known to play a critical role in collagen-induced arthritis in mice.

UOM: 1 * 100 µG

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Catalog Number: (ENZOADI905714100)

Supplier: ENZO LIFE SCIENCES

Description: Adipose tissue is the source for a variety of bioactive molecules that regulate metabolism and immunity termed adipokines, most of which are elevated in the circulation of obese individuals. Adiponectin functions as an insulin sensitizing factor, resulting in reduced hepatic glucose production, increased glucose uptake in the muscle, and increased fatty acid oxidation in the liver and muscle. In contrast to most adipokines, adiponectin is detected at high levels in normal human plasma, but is often reduced in obese subjects and in those with increased insulin resistance and type 2 diabetes. Due to its suggested protective role in insulin resistance, adiponectin may be a useful pharmacological target for various metabolic diseases.

UOM: 1 * 100 µG

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Catalog Number: (ENZOADI905665100)

Supplier: ENZO LIFE SCIENCES

Description: The Src homology 2 domain containing (Shc) adaptor protein links growth factor, cytokine, and antigen receptor stimulation to the Ras signaling pathway, and plays a critical role in insulin signaling, tumorigenesis, and hematopoietic cell growth and differentiation. Structurally, Shc is composed of an N-terminal phosphotyrosine binding (PTB) domain, a medial CH1 domain, and a C-terminal SH2 domain. Upon binding to activate cell-surface receptors, Shc is phosphorylated at three tyrosine residues (Tyr239, Tyr240, Tyr317) triggering recognition of Shc by SH2-containing proteins such as Grb2.

UOM: 1 * 100 µG

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Catalog Number: (ENZOADI905763100)

Supplier: ENZO LIFE SCIENCES

Description: The enzymatic conversion of arginine to citrulline by nitric oxide synthase (NO Synthase) leads to the formation of nitric oxide (NO). Peroxynitrite is formed following reaction of NO with superoxide, producing a potent oxidant that reacts with a variety of biological molecules, including tyrosine residues in proteins. Tyrosine nitration can inactivate enzymes and receptors that depend on tyrosine residues for their activity. Nitration prevents phosphorylation of tyrosine residues important for signal transduction.

UOM: 1 * 100 µG

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Catalog Number: (ENZOADI905776100)

Supplier: ENZO LIFE SCIENCES

Description: Cyclins are a family of proteins which function as the regulatory subunits of cyclin/cyclin-dependent kinase (Cdk) holoenzymes, mediating entry into and progression through the cell cycle. Each cyclin is expressed in a temporal fashion during the cell cycle, partnering with a specific Cdk to activate its protein kinase activity. The most well defined mitotic cyclins are: cyclin D, which partners with cdks 4 and 6 during early G1 phase; cyclin E, which activates Cdk2 in the G1 to S phase transition; cyclin A, which utilizes Cdks 1 and 2 during progression through S phase and into G2; and cyclin B, which activates Cdk1 in M-phase promotion.

UOM: 1 * 100 µG

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Catalog Number: (ENZOADI905794100)

Supplier: ENZO LIFE SCIENCES

Description: Leukotrienes are metabolic products of arachidonic acid formed by the action of 5-lipoxygenase (5-LO), with the principal products being leukotrienes C4 (LTC4) and B4 (LTB4). LTB4 is a dihydroxy-leukotriene produced in a variety of cells including eosinophils, neutrophils, platelets, and vascular cells, and is a potent leukocyte chemoattractant known to regulate leukocyte activation, cytokine secretion, inflammatory gene transcription, and IgE synthesis. As such, LTB4 has been implicated in a number of disease pathologies including atherosclerosis, asthma, psoriasis, and inflammatory bowel disease. The many actions of LTB4 are associated with two identified mammalian receptors, BLT1 and BLT2. BLT1 is a high-affinity LTB4 receptor expressed on peripheral leukocytes, while BLT2 is a more ubiquitously expressed low affinity LTB4 receptor whose function is not well understood. The BLT1 receptor is transiently expressed by antigen-primed T-cells in humans, and its expression is known to play a critical role in collagen-induced arthritis in mice.

UOM: 1 * 100 µG

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