You Searched For: ProSci Inc.

Catalog Number: (PRSI90-483)

Supplier: ProSci Inc.

Description: Interleukin 6 (IL-6) is a pleiotropic alpha-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22kDa-28kDa phosphorylated and variably glycosylated molecule. IL-6 induces signallling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6R) and a signal transducing subunit (gp130). IL-6 is a key factor for the growth of plasma cells.

UOM: 1 * 50 µG

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Catalog Number: (PRSI31-115)

Supplier: ProSci Inc.

Description: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with g proteins that activate a phosphatidylinositol. calcium second messenger system.

UOM: 1 * 100 µG

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Catalog Number: (PRSI31-130)

Supplier: ProSci Inc.

Description: The 5-HT1F receptor is present in both human vascular and neuronal tissue. This gene is localized at 3p12.

UOM: 1 * 100 µG

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Catalog Number: (PRSI31-125)

Supplier: ProSci Inc.

Description: APBA1 is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. APBA1 is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.

UOM: 1 * 50 µG

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Catalog Number: (PRSI43-026)

Supplier: ProSci Inc.

Description: Anti-Trp63 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI43-031)

Supplier: ProSci Inc.

Description: Anti-PLEKHA5 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI43-030)

Supplier: ProSci Inc.

Description: Anti-USP6 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI92-656)

Supplier: ProSci Inc.

Description: T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumour immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.

UOM: 1 * 50 µG

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Catalog Number: (PRSI90-468)

Supplier: ProSci Inc.

Description: Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.

UOM: 1 * 10 µG

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Catalog Number: (PRSI45-518)

Supplier: ProSci Inc.

Description: Anti-UBR5 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI45-515)

Supplier: ProSci Inc.

Description: Anti-EBAG9 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSIXP-5190BT)

Supplier: ProSci Inc.

Description: Anti-IL4 Rabbit Polyclonal Antibody (Biotin)

UOM: 1 * 50 µG

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Catalog Number: (PRSIXP-5197)

Supplier: ProSci Inc.

Description: Iterleukin 7 is a lymphoid cell growth factor that affects pre-B, pro-B, and early T cells. IL-7 was previously known as pre-B cell growth factor and lymphopoietin 1. IL-7 supports the growth of early B cells from long-term lymphoid bone marrow cultures. It is mitogenic to thymocytes and enhances the response of cells to other stimuli such as polyhydroxyalkanoate (PHA) and concanavalin A (ConA). IL-7 stimulates the proliferation of CD4+/CD8+ cells.

UOM: 1 * 100 µG

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Catalog Number: (PRSI92-102)

Supplier: ProSci Inc.

Description: Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. NCK1 plays a role in the DNA damage response, but not in the detection of the damage by ATM/ATR. It is also involved in transducing signals from receptor tyrosine kinases to downstream signal recipients, such as ELK1-dependent transcriptional activation in response to activated Ras signaling.

UOM: 1 * 50 µG

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Catalog Number: (PRSI92-098)

Supplier: ProSci Inc.

Description: Pleckstrin Homology-Like Domain Family A Member 2 (PHLDA2) is a peripheral membrane protein that belongs to the PHLDA2 family. PHLDA2 is expressed in the placenta and adult prostate gland. In the placenta, it is present in all cells of the villous cytotrophoblast. PHLDA2 plays a role in regulating placenta growth. PHLDA2 may act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.

UOM: 1 * 50 µG

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Catalog Number: (PRSI92-105)

Supplier: ProSci Inc.

Description: SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. SMAD4 promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. SMAD4 may act as a tumor suppressor. It positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Mutations or deletions in SMAD4 have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

UOM: 1 * 50 µG

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