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Supplier: STEMCELL Technologies

Description: Fractalkine (CX3CL1) is a unique chemokine belonging to the CX3C family, and is characterized by a C-X3-C cysteine motif within the chemokine domain, near the amino terminus of the protein (Bazan <i>et al.</i>). The chemokine domain is connected to an extended mucin-like stalk, followed by a transmembrane region, and a C-terminal intracellular domain (Imai <i>et al.</i>; Jones <i>et al.</i>). The protein signals through interaction with a single receptor, CX3CR1, expressed on monocytes, natural killer cells, T cells, microglia, and smooth muscle cells. Fractalkine is upregulated in endothelial cells by inflammatory signals and is synthesized as a membrane-bound molecule that mediates cell migration and adhesion (White and Greaves). Cleavage at the base of the stalk by metalloproteinases generates a soluble chemokine, which functions as a potent chemoattractant of target cells (Garton <i>et al.</i>; Apostolakis and Spandidos). Fractalkine has been implicated in pathology of inflammatory diseases, such as atherosclerosis and other vascular diseases, and has anti-apoptotic functions (White and Greaves).

Catalog Number: (STMC78098.1)

Supplier: STEMCELL Technologies

Description: Prolactin is a peptide hormone of pituitary origin and is well known for the stimulation, initiation, and maintenance of lactation. Prolactin is also known to regulate mammary gland development and immune system, and has an essential role in metabolism and behavioral modification (Bernichtein <i>et al.</i>). Prolactin actions are mediated by the prolactin receptor (PRLR), which is a single-chain transmembrane protein composed of an extracellular, transmembrane, and intracellular domain. It has also been indicated that high to normal circulating levels of prolactin increase breast cancer risk, and dopamine agonists have been suggested to be effective for treatment (Bernichtein <i>et al.</i>). Prolactin levels have been reported to be higher in multiple sclerosis patients, which promotes B cell autoreactivity (Correale <i>et al.</i>). It has been shown that administration of recombinant prolactin after bone marrow transplantation in mice promotes immune and myeloid reconstitution (Sun <i>et al.</i>).

UOM: 1 * 50 µG

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Catalog Number: (STMC03236)

Supplier: STEMCELL Technologies

Description: Serum-free methylcellulose-based medium without cytokines for mouse cells.

UOM: 1 * 80 mL

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Supplier: STEMCELL Technologies

Description: For digestion of native collagen fibrils.

Supplier: STEMCELL Technologies

Description: Activin A is a member of the transforming growth factor beta (TGF-β) family of proteins produced by many cell types throughout development (Gurdon <i>et al.</i>). It is a disulfide-linked homodimer (two beta-A chains) that binds to heteromeric complexes of a type I (Act RI-A and Act RI-B) and a type II (Act RII-A and Act RII-B) serine-threonine kinase receptor (Attisano <i>et al.</i>). Activins primarily signal through SMAD2/3 proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, and metabolism (McDowell <i>et al.</i>). Activin A maintains the undifferentiated state of human embryonic stem cells (James <i>et al.</i>; Xiao <i>et al.</i>) and also facilitates differentiation of human embryonic stem cells into definitive endoderm (D’Amour <i>et al.</i>).

Supplier: STEMCELL Technologies

Description: Neurotrophin-3 (NT-3) is a neurotrophic factor and a member of the nerve growth factor (NGF) family of proteins that includes neuron growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-4/5. NT-3 signals a number of trophic effects through its transducing receptor tyrosine kinase TrkC. NT-3 is known to promote survival, development, and differentiation of neurons, and modulates transmitter release at several types of synapses in the peripheral and central nervous systems (Chalazonitis 1996). NT-3 has been shown to have an important role in the overall development of enteric neurons, which are crucial for gut peristalsis (Chalazonitis 2004). Studies in rats have shown the potential of NT-3 in dorsal column axonal regeneration (Bradbury <i>et al.</i>). NT-3 was shown to protect neurons against amyloid-β toxicity (Lesne <i>et al.</i>). NT-3 has applications in neuronal differentiation protocols to generate β-tubulin III+ peripheral neurons from neural crest stem cells (Menendez <i>et al.</i>) and oligodendrocyte precursor cells from human embryonic stem (ES) and induced pluripotent stem (iPS) cells (Douvaras <i>et al.</i>).

Catalog Number: (STMC05630)

Supplier: STEMCELL Technologies

Description: For culture of human mammary epithelial cells.

UOM: 1 * 1 KIT

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Catalog Number: (STMC100-0924)

Supplier: STEMCELL Technologies

Description: For detection of active caspase-3 in mammalian cells undergoing apoptosis.

UOM: 1 * 100 µG

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Catalog Number: (STMC100-0990)

Supplier: STEMCELL Technologies

Description: Isolation kit to enrich the mitochondrial subcellular fraction from mammalian cells or tissue - 50 tests.

UOM: 1 * 50 items

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Catalog Number: (STMC100-0684)

Supplier: STEMCELL Technologies

Description: Maturation kit for generation of functional sensory neurons from human iPS cell-derived neuronal precursor cells.

UOM: 1 * 1 KIT

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Catalog Number: (STMC100-0921)

Supplier: STEMCELL Technologies

Description: For detection of caspase-3/7 activity in cell lysates prepared from mammalian cells undergoing apoptosis - 200 tests.

UOM: 1 * 200 items

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Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, chimpanzee CD3, PE-conjugated.

Catalog Number: (STMC08005)

Supplier: STEMCELL Technologies

Description: Serum- and xeno-free kit for differentiation and expansion of human pluripotent stem cell-derived endothelial cells.

UOM: 1 * 1 KIT

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Supplier: STEMCELL Technologies

Description: Immunomagnetic positive selection of particle-free human CD4+ cells.

Supplier: STEMCELL Technologies

Description: Persephin is a neurotrophic factor that belongs to the glial cell line-derived neurotrophic factor (GDNF) family. Persephin shares a large degree of structural similarity to GDNF, artemin, and neurturin, and has overall neuroprotective activity. Persephin signals through GRFα4 (glycosylphosphatidylinositol (GPI)-linked GDNF receptor family member) which signals through the receptor tyrosine kinase RET. Unlike GDNF and neurturin, persephin only promotes the growth and survival of central dopaminergic and motor neurons, but not peripheral neurons (Milbrandt <i>et al.</i>). In vitro, persephin only promotes survival of neurons that co-express GPI-linked GRFα4 and RET (Enokido <i>et al.</i>; Lindahl <i>et al.</i>). Mice lacking persephin showed increased cell death after cerebral ischemia, however administration of persephin before ischemia dramatically reduced neuronal cell death (Tomac <i>et al.</i>).

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Supplier: STEMCELL Technologies

Description: Monokine induced by interferon-gamma (MIG), or CXCL9, is a member of the CXC chemokine family. MIG is closely related to two other chemokines: CXCL10 and CXCL11, all of which signal through the CXCR3 receptor (Ding <i>et al.</i>). MIG is secreted by a variety of immune cells including T cells, NK cells, dendritic cells, macrophages, and eosinophils, as well as non-immune cells including hepatic stellate cells, preadipocytes, thyrocytes, endothelial cells, tumor cells, fibroblasts, and glial cells of the central nervous system. MIG has also been shown to act as a chemoattractant for activated T cells and for tumor-infiltrating leukocytes (TILs), but not for neutrophils or for monocytes. MIG has also been reported to be both a tumor suppressor and tumor promoter in various types of cancer.

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