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Supplier: Tonbo Biosciences

Description: The RA3-6B2 antibody reacts with the human and mouse CD45 isoform known as CD45R, or B220, a protein tyrosine phosphatase of 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns, all critical for leukocyte function. In mouse, the CD45R/B220 isoform is predominantly found on B cells, at varying levels on all stages from pro-B cells to activated B cells, and may also be detected on certain T cell and NK cell subsets. It is of note that B220 is not similarly expressed on human B cells, where it appears to be differentiation-specific and therefore expressed on only some B cell subsets. Other forms of CD45 with restricted cellular expression include CD45RA, CD45RB, CD45RO and several others. The RA3-6B2 antibody is one of the most consistently used leukocyte markers for B cells, T cell subsets and NK cell subsets in human and mouse. This antibody has also been reported as cross-reactive with feline CD45R/B220.

Supplier: Tonbo Biosciences

Description: The PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1 (Ehlers et al. 2012. Endocrinology. 10: 1247). The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524).

Supplier: Tonbo Biosciences

Description: The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.</p><p>The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.

Supplier: Tonbo Biosciences

Description: The ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development. The ACK2 antibody is widely utilized as a marker to identify hematopoietic progenitors, and to neutralize receptor-ligand binding in vitro and in vivo. Please choose the appropriate format for each application. In addition, the antibody is reported to be cross-reactive with rat c-Kit and is extensively published for use in this species.

Catalog Number: (72-8078-M001)

Supplier: Tonbo Biosciences

Description: Sheep anti-Rabbit IgG (H&L) - Affinity Pure, HRP Conjugate

UOM: 1 * 1 mg

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Catalog Number: (72-8068-M001)

Supplier: Tonbo Biosciences

Description: Goat anti-Rabbit IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/ bovine, goat, human, mouse or rat IgG or serum

UOM: 1 * 1 mg

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Catalog Number: (50-8036-U100)

Supplier: Tonbo Biosciences

Description: Goat anti-Rabbit IgG, secondary antibody, conjugated toSureLight® R-Phycoerythrin

UOM: 1 * 100 µG

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Catalog Number: (72-8085-M001)

Supplier: Tonbo Biosciences

Description: Donkey anti-Sheep IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/human, mouse, or rabbit IgG

UOM: 1 * 1 mg

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Catalog Number: (70-8078-M002)

Supplier: Tonbo Biosciences

Description: Sheep anti-Rabbit IgG (H&L) - Affinity Pure

UOM: 1 * 2 mg

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Catalog Number: (72-8074-U500)

Supplier: Tonbo Biosciences

Description: Goat anti-Rabbit IgG (H&L), F(ab')2 Fragment - Affinity Pure, HRP Conjugate, min x w/ bovine, human, or mouse IgG or serum proteins

UOM: 1 * 0,5 mg

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Catalog Number: (30-8064-M002)

Supplier: Tonbo Biosciences

Description: Goat anti-Mouse IgM (H&L) - Affinity Pure, Biotin Conjugate

UOM: 1 * 2 mg

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Catalog Number: (35-8023-M001)

Supplier: Tonbo Biosciences

Description: Goat anti-Human IgA (alpha chain) - Affinity Pure, FITC Conjugate, min x w/bovine, mouse, and rabbit serum proteins

UOM: 1 * 1 mg

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Catalog Number: (72-8120-M001)

Supplier: Tonbo Biosciences

Description: Goat anti-Human IgG Fc - Affinity Pure, HRP Conjugate

UOM: 1 * 1 mg

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Supplier: Tonbo Biosciences

Description: The 2.4G2 antibody is specific for a common epitope found in the extracellular regions of mouse Fc-receptors Fc-gamma II (CD32) and Fc-gamma III (CD16). These receptors are expressed by B cells, monocytes, macrophages, NK cells, dendritic cells, and neutrophils.

Catalog Number: (22-8042-M001)

Supplier: Tonbo Biosciences

Description: Goat anti-Mouse IgG (H&L) - Affinity Pure, Alkaline Phosphatase Conjugate

UOM: 1 * 1 mg

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Catalog Number: (30-8065-M002)

Supplier: Tonbo Biosciences

Description: Goat anti-Mouse IgM (mu chain) - Affinity Pure, Biotin Conjugate

UOM: 1 * 2 mg

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