You Searched For: AGILENT

Description: The O323 antibody reacts with human CD27 (TNFRSF7), a cell surface homodimer of 55 kDa subunits, which provides co-stimulatory signaling in support of the T cell (TCR) and B cell (BCR) receptors. By comparison with CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling appears to promote cell survival and differentiation to effector / memory stages. Also in contrast with CD28, the CD27 receptor may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells and B cells. With respect to B cells, CD27 is considered to be a phenotypic marker for memory B cells. CD27 has been included within a group of phenotypic markers for identifying human B regulatory cells (Bregs), a cell type proposed to regulate CD4+ T cell proliferation and Foxp3 / CTLA-4 expression in Treg cells.

Catalog Number: 35-0279-T100

UOM: 1 * 100 Tests

Supplier: Tonbo Biosciences

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Description: The J43.1 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein which can co-regulate T cell antigen receptor signaling and therefore modulate T cell activation. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells. PD-1 is a member of a family of receptors including CD28 and CTLA-4 (CD152), which interact with 'B7' ligands to provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.

Catalog Number: 40-9985-U100

UOM: 1 * 100 µG

Supplier: Tonbo Biosciences

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Description: The TER-119 antibody is named for the antigen to which it binds, a 52 kDa surface protein that is associated with glycophorin-A. TER-119 is considered to be a lineage marker for later stages of erythroid cell development, as its expression begins at the pro-erythroblast stage. TER-119 antigen is not expressed at either BFU-E or CFU-E stages, i.e. prior to the pro-erythroblast stage.

Catalog Number: 80-5921-U025

UOM: 1 * 25 µG

Supplier: Tonbo Biosciences

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Description: The MEL-14 antibody is specific for mouse CD62L, also known as L-Selectin, a cell adhesion molecule which facilitates lymphocyte 'rolling' on activated vascular endothelium and homing to high endothelial venules (HEV) as immune cells transmigrate from blood into peripheral tissues. L-Selectin is a member of a family of Selectin molecules which act together with the integrin family of adhesion molecules to mediate leukocyte-endothelial interactions. L-Selectin is characteristically expressed by neutrophils, and is also found on B cells, monocytes, granulocytes, and at varying levels on naive, effector and memory T cells. It is rapidly shed upon cell activation, releasing into the circulation a soluble form whose biological role is of particular interest in cancer biology research.

Catalog Number: 80-0621-U100

UOM: 1 * 100 µG

Supplier: Tonbo Biosciences

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Description: The 1A8 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils.

Catalog Number: 80-1276-U025

UOM: 1 * 25 µG

Supplier: Tonbo Biosciences

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Description: The PIP immunoglobulin is useful as an isotype-matched control. The PIP immunolglobulin is specific for Glutathione S-transferase and can be used as an isotype control for Armenian Hamster IgG antibodies.

Catalog Number: 65-4888-U100

UOM: 1 * 100 µG

Supplier: Tonbo Biosciences

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Description: The 3.9 antibody reacts with human CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells. The 3.9 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on activated neutrophils, granulocytes, some types of activated T cells and intestinal intraepithelial lymphocytes (IEL). The antibody is reported to be cross-reactive with Baboon, Chimpanzee, Cynomolgus and Rhesus CD11c.

Catalog Number: 25-0116-T100

UOM: 1 * 100 Tests

Supplier: Tonbo Biosciences

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Description: The M1/69 antibody reacts with mouse CD24, a cell surface molecule also known as Heat Stable Antigen (HSA). CD24 is a GPI-linked glycoprotein involved in cell adhesion and is a ligand for CD62P (P-selectin). It is expressed on erthrocytes, thymocytes, peripheral lymphocytes and myeloid lineage cells. The expression of CD24 is used to delineate stages of of lymphocyte development in the bone marrow.

Catalog Number: 20-0242-U100

UOM: 1 * 100 µG

Supplier: Tonbo Biosciences

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Description: The HI100 antibody reacts with the human CD45 isoform known as CD45RA, a protein tyrosine phosphatase of 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RB, CD45RO and others. The HI100 antibody is widely used as a marker for human CD45RA expression on naive and activated T cells, B cells, and monocytes.

Catalog Number: 25-0458-T100

UOM: 1 * 100 Tests

Supplier: Tonbo Biosciences

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Description: Goat anti-Mouse IgG (H&L) - Affinity Pure, min x w/bovine, horse, human, pig or rabbit serum protein

Catalog Number: 70-8040-M002

UOM: 1 * 2 mg

Supplier: Tonbo Biosciences

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Description: Rabbit anti-Goat IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/human, mouse, or rat IgG

Catalog Number: 72-8106-M001

UOM: 1 * 1 mg

Supplier: Tonbo Biosciences

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Description: Donkey anti-Goat IgG (H&L) - Affinity Pure, Biotin Conjugate, min x w/human, mouse, rabbit or rat IgG

Catalog Number: 30-8080-M001

UOM: 1 * 1 mg

Supplier: Tonbo Biosciences

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Description: Goat anti-Human IgG Fc, F(ab')2 Fragment - Affinity Pure, HRP Conjugate, min x w/bovine, horse, mouse or rabbit serum proteins

Catalog Number: 72-8105-U500

UOM: 1 * 0,5 mg

Supplier: Tonbo Biosciences

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Description: Rabbit anti-Goat IgG (H&L) - Affinity Pure, HRP Conjugate

Catalog Number: 72-8095-M001

UOM: 1 * 1 mg

Supplier: Tonbo Biosciences

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Description: Rabbit anti-Mouse IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/human serum proteins

Catalog Number: 72-8077-M001

UOM: 1 * 1 mg

Supplier: Tonbo Biosciences

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Description: Goat anti-Rabbit IgG (H&L) - Affinity Pure, FITC Conjugate, min x w/bovine, human, or mouse IgG

Catalog Number: 35-8070-M002

UOM: 1 * 2 mg

Supplier: Tonbo Biosciences

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