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Catalog Number: (65-0289-T025)

Supplier: Tonbo Biosciences

Description: The CD28.2 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA.

UOM: 1 * 25 Tests

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Supplier: Tonbo Biosciences

Description: The BNI3 antibody is specific for human CD152, commonly known as CTLA-4, a 33 to 37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.

Supplier: Tonbo Biosciences

Description: The UCHL1 antibody reacts with the human CD45 isoform known as CD45RO, a protein tyrosine phosphatase of 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA and CD45RB.

Supplier: Tonbo Biosciences

Description: The MAR-1 antibody reacts with the Fc epsilon Receptor I alpha chain (FceRIa), a transmembrane protein member of the Ig superfamily. This chain, together with a beta chain and two gamma chains form a tetrameric complex that supports IgE-mediated signaling and subsequent release of chemical mediators of allergy and immediate hypersensitivity. FceR1a is upregulated in the presence of IgE on those cell types which express it, such as Mast cells and Basophils.

Supplier: Tonbo Biosciences

Description: The 3G3 antibody reacts with mouse Foxp3, a 50-55 kDa transcription factor which is a central regulator of T cell activity and is critical for the development and function of regulatory T cells (Tregs). Foxp3 is expressed at constitutively high levels in Treg cells, which are further identified as being CD4+ CD25+. In resting conventional T cells (CD4+ CD25-) Foxp3 expression is restricted, and upon TCR activation is expressed only transiently and in a small proportion of cells. However, the growth factor TGF-beta has been shown to induce expression of Foxp3 in naïve T cells, driving their development into Foxp3+ Tregs, which are called “induced” or “adaptive” Tregs. These cells are phenotypically similar to so-called “natural” Tregs (CD4+ CD25high Foxp3+) which originate in the thymus and comprise the majority of Treg cells. Tregs are critical for maintaining peripheral tolerance and are implicated in the development of autoimmunity.

Supplier: Tonbo Biosciences

Description: The UCHT1 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.

Catalog Number: (35-8016-M001)

Supplier: Tonbo Biosciences

Description: Goat anti-Human IgA (alpha chain) - Affinity Pure, FITC Conjugate

UOM: 1 * 1 mg

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Catalog Number: (30-8057-U500)

Supplier: Tonbo Biosciences

Description: Goat anti-Mouse IgG (H&L) - F(ab')2 fragment, Biotin Conjugate, min x w/bovine, goat, human, rabbit, or rat IgG

UOM: 1 * 0,5 mg

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Catalog Number: (30-8054-U500)

Supplier: Tonbo Biosciences

Description: Goat anti-mouse IgG (H&L), F(ab')2 fragment - Affinity Pure, Biotin Conjugate

UOM: 1 * 0,5 mg

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Catalog Number: (30-8026-M001)

Supplier: Tonbo Biosciences

Description: Goat anti-Human IgE (epsilon chain) - Affinity Pure, Biotin Conjugate

UOM: 1 * 1 mg

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Catalog Number: (30-8027-M001)

Supplier: Tonbo Biosciences

Description: Goat anti-Human IgE (epsilon chain) - Affinity Pure, Biotin Conjugate, min x w/bovine, mouse or rabbit serum proteins

UOM: 1 * 1 mg

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Catalog Number: (72-8087-M001)

Supplier: Tonbo Biosciences

Description: Donkey anti-Rabbit IgG (H&L) - Affinity Pure, HRP Conjugate

UOM: 1 * 1 mg

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Catalog Number: (72-8067-M001)

Supplier: Tonbo Biosciences

Description: Goat anti-Rabbit IgG (H&L) - Affinity Pure, HRP Conjugate

UOM: 1 * 1 mg

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Catalog Number: (35-8078-M002)

Supplier: Tonbo Biosciences

Description: Sheep anti-Rabbit IgG (H&L) - Affinity Pure, FITC Conjugate

UOM: 1 * 2 mg

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Catalog Number: (70-8077-M002)

Supplier: Tonbo Biosciences

Description: Rabbit anti-mouse IgG (H&L) - Affinity Pure, min x w/human serum proteins

UOM: 1 * 2 mg

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Catalog Number: (35-8075-M001)

Supplier: Tonbo Biosciences

Description: Rabbit anti-Human IgM (mu chain) - Affinity Pure, FITC Conjugate

UOM: 1 * 1 mg

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