2,6-Di-tert-butyl-p-cresol, crystalline powder

Supplier: MP Biomedicals

0210116280 0210116290 0210116291
ICNA0210116280EA 22.7 EUR
ICNA0210116280 ICNA0210116290 ICNA0210116291
2,6-Di-tert-butyl-p-cresol, crystalline powder
2,6-Di-tert-butyl-p-cresol

Butylated hydroxytoluene is a phenolic antioxidant.


Butylated hydroxytoluene (BHT) has been shown to inhibit lipid peroxidation. It causes lung injury and promotes tumors in mice, but this may be due to a metabolite of BHT, 6-tert-butyl-2-[2′-(2′-hydroxymethyl)-propyl]-4-methylphenol. Metabolites of BHT have also been reported to induce DNA strand breaks and internucleosomal DNA fragmentation (a characteristic of apoptosis) in cultured cells. In rats, a single intraperitoneal injection of BHT (60 mg/kg body mass) results in a significant increase in nuclear DNA methyl transferase activity in the liver, kidneys, heart, spleen, brain and lungs. Incubation of alveolar macrophages with BHT significantly reduced the level of TNF-α which may explain the mechanism by which this antioxidant reduces inflammation. Preincubation of aspirin-treated platelets with BHT inhibits the secretion, aggregation, and protein phosphorylation induced by protein kinase C activators. BHT was also found to inhibit the initiation of hepatocarcinogenesis by aflatoxin B1.


Insoluble in water; freely soluble in toluene, soluble in methanol, ethanol (100 mg/ml), isopropanol, methyl ethyl ketone, acetone, Cellosolve, benzene and most other hydrocarbon solvents. More soluble in food oils and fats than butylated hydroxyanisole.


Caution: Research Use Only (RUO).

Formula: C₁₅H₂₄O
Storage Temperature: Ambient
MDL Number: MFCD00011644
CAS Number: 128-37-0

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Specification Test Results

Identity Test Passes
FTIR Conforms to Standard
Melting Point 68 - 74 °C

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