13-cis-Retinoic acid, orange powder
Supplier: MP Biomedicals
Synonyms:
Isotretinoin, (2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid, (2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action.
The action of 13-cis-Retinoic acid (RA) is mediated through RAR-β and RAR-α receptors. RA attenuates iNOS expression and activity in cytokine-stimulated murine mesangial cells. It induces mitochondrial membrane permeability transition, observed as swelling and as a decrease in membrane potential, and stimulates the release of cytochrome c implicating mechanisms through the apoptosis pathway. These activities are reversed by EGTA and cyclosporin A. RA also increases MMP-1 protein expression partially via increased transcription.
Soluble in chloroform (50 mg/ml); sparingly soluble in ether; slightly soluble in ethanol and isopropanol; practically insoluble in water.
Formula:
C₂₀H₂₈O₂ MW: 300,44 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00079542 CAS Number: 4759-48-2 |
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