Sodium cholate ≥98.5%, white powder
Supplier: MP Biomedicals
Synonyms:
3α,7α,12α-Trihydroxy-5β-cholanic acid sodium salt, 3α,7α,12α-Trihydroxycholan-24-oic acid sodium salt, 3α,7α,12α-Trihydroxycholanic acid sodium salt, Sodium 3α,7α,12α-trihydroxy-5β-cholanoate, Sodium 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoate, Cholic acid sodium salt, 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt, (R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid, sodium salt
Cholic acid is a biochemical solubilizing agent (a non-ionic, non-denaturing detergent). Occurs inconjugation with glycine or taurine in bile of most vertebrates.
- Critical Micelle Concentration (CMC): 14mM
Cholic acid is used in the solubilization of membrane-bound proteins in their native state. It is a component for the preparation of liposomes. It has also been used in a study to investigate the elastic deformable vesicles, transfersomes, for transdermal drug delivery.
Cholate is a bile acid produced in liver during cholesterol breakdown. Cholate downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis). Cholate, an anionic detergent, is used alone and in combination with urea to extract and reconstitute membrane proteins and protein complexes.
Cholic acid is a biochemical solubilising agent (a non-ionic, non-denaturing detergent). Occurs inconjugation with glycine or taurine in bile of most vertebrates.
Soluble in water (100 mg/ml). Soluble in ethanol (40 mg/ml - clear, colorless solution).
Formula:
C₂₄H₃₉NaO₅ MW: 430,56 g/mol Melting Pt: 198 °C Storage Temperature: Ambient |
MDL Number:
MFCD00150749 CAS Number: 361-09-1 EINECS: 206-643-5 |
Specification Test Results
Identity Test | Passes |
Purity (HPLC) | ≥98,5% |
Loss on Drying | ≤5% |
pH (2% aq soln) | 7,5 - 9,0 |
Solubility (2% aq soln) | Clear and Colorless |
Sodium Deoxycholate | ≤1,5% |
Heavy Metals | ≤50 ppm |
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