Tyrphostin AG-126 ≥98% (by HPLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
2-(3-Hydroxy-4-nitrobenzylidene)malononitrile
AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.
- Inhibits tyrosine kinase-dependent B cell receptor signaling
Yellow solid.
Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml warm).
Formula:
C₁₀H₅N₃O₃ MW: 215,168 g/mol Storage Temperature: Ambient |
MDL Number:
MFCD00236448 CAS Number: 118409-62-4 |
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