Tyrphostin AG-126 ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES AG

Synonyms: 2-(3-Hydroxy-4-nitrobenzylidene)malononitrile

BMLEI2630005 BMLEI2630025
ENZOBMLEI2630005EA 110 EUR
ENZOBMLEI2630005 ENZOBMLEI2630025
Tyrphostin AG-126 ≥98% (by HPLC)
Tyrphostin AG-126

AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.


  • Inhibits tyrosine kinase-dependent B cell receptor signaling


Yellow solid.


Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml warm).

Formula: C₁₀H₅N₃O₃
MW: 215,168 g/mol
Storage Temperature: Ambient
MDL Number: MFCD00236448
CAS Number: 118409-62-4
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