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Catalog Number: (ENZOALX350150M001)

Supplier: ENZO LIFE SCIENCES

Description: Type I ribosome inactivating protein (RIP). Depurinates RNA in ribosomes, thus inhibiting protein synthesis in eukaryotic cells, which results in cell death. Widely used to construct immunotoxins composed of cell-targeted antibodies. As a type I RIP it lacks the lectin subunit and is practically non-toxic to intact cells.

UOM: 1 * 1 mg

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Supplier: ENZO LIFE SCIENCES

Description: Calnexin (CNX), an unglycosylated resident ER transmembrane protein, together with Calreticulin (CRT), plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their monoglucosylated glycans. Calnexin associates with newly synthesized monomeric glycoproteins and only recognizes glycoproteins when they are incompletely folded. Furthermore, Calnexin has been demonstrated to function as a molecular chaperone capable of interacting with polypeptide segments of folding glycoproteins.

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Catalog Number: (ENZOADISPA850F)

Supplier: ENZO LIFE SCIENCES

Description: Grp94 (Glucose-regulated protein 94) is an abundant resident endoplasmic reticulum (ER) lumenal stress protein, which together with cytosolic Hsp90 belongs to the Hsp90 family of molecular chaperones. Grp94 expression is upregulated by stress conditions such as glucose starvation and heat shock, which promote protein misfolding or unfolding. In addition to a homeostatic role in protein folding and assembly, Grp94 can function in the intracellular trafficking of peptides from the extracellular space to the MHC class I antigen processing pathway of antigen presentation cells.

UOM: 1 * 200 µG

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Supplier: ENZO LIFE SCIENCES

Description: The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

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Supplier: ENZO LIFE SCIENCES

Description: Anti-HSP90B Rabbit Polyclonal Antibody

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Supplier: ENZO LIFE SCIENCES

Description: The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

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Supplier: ENZO LIFE SCIENCES

Description: The mammalian protein disulphide-isomerase (PDI) family encompasses several highly divergent proteins involved in the processing and maturation of secretory proteins in the ER by catalyzing the rearrangement of disulphide bonds. PDI, an abundant protein of the ER (>400uM), contains a carboxy-terminal retention signal sequence, KDEL, similar to that of BiP and Grp94. The PDI proteins are characterized by the presence of one or more domains of ~95-110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing - and one domain lacking - a redox-active-Cys-X-X-Cys-tetrapeptide. In addition to roles as redox catalysts and isomerases, PDI proteins perform such functions as peptide binding and cell adhesion, and may conduct chaperone activities. Platelet surface thiols and disulphides play an important role in platelet responses. Catalytically active PDI resides on platelet surfaces where it mediates platelet aggregation and secretion by reducing disulfide bonds, thus exposing fibrinogen receptors in platelets.

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Supplier: ENZO LIFE SCIENCES

Description: Nonhydrolysable GTP analog.

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Catalog Number: (ENZOALX480072M001)

Supplier: ENZO LIFE SCIENCES

Description: Inhibitor of cGMP-dependent protein kinase (PKG) 1α (cGMP antagonist). Resistant against mammalian cyclic nucleotid-dependent phosphodiesterases. No metabolic side effects. Low membrane permeability.

UOM: 1 * 1 mg

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Catalog Number: (ENZOALX521006C010)

Supplier: ENZO LIFE SCIENCES

Description: Isolated from mouse submaxillary glands by a modification of the procedure described by T. Darling, et al.; Cell Culture Meth. Mol. Cell Biol. 4, 79 (1984).

UOM: 1 * 10 µG

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Catalog Number: (ENZOENZPRT1370010)

Supplier: ENZO LIFE SCIENCES

Description: Produced in <i>E.coli</i>.

UOM: 1 * 10 µG

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Catalog Number: (ENZOENZPRT1400010)

Supplier: ENZO LIFE SCIENCES

Description: Produced in <i>E.coli</i>.

UOM: 1 * 10 µG

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Catalog Number: (ENZOENZPRT1410100)

Supplier: ENZO LIFE SCIENCES

Description: Produced in <i>E.coli</i>.

UOM: 1 * 100 µG

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Catalog Number: (ENZOENZPRT1700010)

Supplier: ENZO LIFE SCIENCES

Description: Produced in HEK 293 cells.

UOM: 1 * 10 µG

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Catalog Number: (ENZOENZPRT1800020)

Supplier: ENZO LIFE SCIENCES

Description: Produced in <i>E. coli</i>.

UOM: 1 * 20 µG

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Supplier: ENZO LIFE SCIENCES

Description: PCR/Gel Clean Up Kits are quick and simple kits for purifying DNA from PCR, gels and labelling reactions for a variety of downstream applications.

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