BX-795 ≥97% (by HPLC)

Supplier: ENZO LIFE SCIENCES AG

Synonyms: BX795, N-(3-((5-Iodo-4-((3-(thiophene-2-carboxamido)propyl)amino)pyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide

ENZCHM1890005 ENZCHM1890010
ENZOENZCHM1890005EA 89.1 EUR
ENZOENZCHM1890005 ENZOENZCHM1890010
BX-795 ≥97% (by HPLC)
BX-795

Inhibitor of PDK1, TBK1, IKK-ε, IRF3


BX795 was initially developed as a PDK1 inhibitor (direct competitive inhibitor IC50 = 11nM for PDK1) and has been shown to be a potent and relatively specific inhibitor of TBK1 and IKK-ε. It blocks the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3. BX795 also is a potent inhibitor of cell growth of multiple cancer cell lines with IC50 values ranging from submicromolar amounts (0.368 µM to greater than 450 µM).

Formula: C₂₃H₂₆IN₇O₂S
MW: 591,5 g/mol
MDL Number: MFCD12546134
CAS Number: 702675-74-9
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