U-73122 ≥99% (by TLC)

Supplier: ENZO LIFE SCIENCES AG

Synonyms: 1-(6-(((8R,9S,13S,14S,17S)-3-Methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione, 1-[6-[((17beta)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]pyrrole-2,5-dione

BMLST3910005 BMLST3910025
ENZOBMLST3910005EA 110 EUR
ENZOBMLST3910005 ENZOBMLST3910025
U-73122 ≥99% (by TLC)
U-73122

Inhibitor of PLC activation


Inhibits agonist induced phospholipase C (PLC) activation (IC50=1-2.1 µM) in human platelets. It also inhibits agonist induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. It is a useful tool to investigate receptor-mediated PI turnover in signal transduction. It is a potent inhibitor of human neutrophil adhesion to biological surfaces as well as adhesion-dependent granule exocytosis and oxidative burst. Inhibits 5-lipoxygenase in vivo and in vitro (IC50 = 30nM for recombinant enzyme and 2.4µM for PMNL homogenates).

Formula: C₂₉H₄₀N₂O₃
MW: 464,65 g/mol
MDL Number: MFCD00893825
CAS Number: 112648-68-7

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