SB239063 ≥97% (by HPLC)

Supplier: ENZO LIFE SCIENCES AG

Synonyms: 4-[4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)imidazol-1-yl]cyclohexan-1-ol, trans-4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-cyclohexanol, Rel-(1r,4r)-4-(4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)-1H-imidazol-1-yl)cyclohexan-1-ol, 4-(4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)-1H-imidazol-1-yl)cyclohexanol

ALX270351C500 ALX270351M001 ALX270351M005
ENZOALX270351C500EA 117.7 EUR
ENZOALX270351C500 ENZOALX270351M001 ENZOALX270351M005
SB239063 ≥97% (by HPLC)
SB239063

A potent, cell permeable inhibitor of p38 MAP kinase (IC50=44nM for recombinant purified human p38α). Inhibits IL-1 and TNF-α production in LPS-stimulated human peripheral blood monocytes (IC50=120nM and 350nM, respectively). Reported to protect against mild excitotoxic neuronal injury caused by NMDA and provides substantial protection against cell death induced by either oxygen glucose deprivation (OGD) or magnesium deprivation in cultured neurons. Also, reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade of polymorphonuclear (PMN) accumulation.


  • p38 inhibitor


White to off-white solid.


Soluble in DMSO, 100% ethanol or dichlormethane (may require slight warming).

Formula: C₂₀H₂₁FN₄O₂
MW: 368,4 g/mol
Storage Temperature: Freezer
MDL Number: MFCD03792786
CAS Number: 193551-21-2

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