PD 184,352 ≥95% (by HPLC, NMR)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
2-(2-Chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide, 2-((2-Chloro-4-iodophenyl)amino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide, PD 184352, CI-1040
ALX270471M001
ALX270471M005
ENZOALX270471M001EA
148.5
EUR
ENZOALX270471M001
ENZOALX270471M005
PD 184,352 ≥95% (by HPLC, NMR)
PD 184,352
Potent and selective inhibitor of MAPK (ERK kinase 1; MEK1) activation (IC50=300nM in vitro, IC50=2nM in vivo). Suppresses activation of MAPK but does not block its activity. Strongly suppresses growth of human implanted colon tumors in mice.
Synthetic.
Formula:
C₁₇H₁₄ClF₂IN₂O₂ MW: 478,7 g/mol |
MDL Number:
MFCD02683961 CAS Number: 212631-79-3 |
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