trans-Ned-19

Supplier: ENZO LIFE SCIENCES AG

Synonyms: 1-(3-((4-(2-Fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

ALX270503M001 ALX270503MC05
ENZOALX270503M001EA 412.5 EUR
ENZOALX270503M001 ENZOALX270503MC05
trans-Ned-19
trans-Ned-19

Cell permeable, selective and potent inhibitor of nicotinic acid adenine dinucleotide phosphate (NAADP) receptor in mammalian cells and sea urchin eggs. Blocks NAADP signaling. Inhibits Ca2+ release: trans-Ned-19 (IC50 = 6nM); cis-Ned-19 (IC50 = 800nM). [32P] NAADP binding: trans-Ned-19 (IC50 = 0.4nM); cis-Ned-19 (IC50 = 15µM).
Inhibits Ca2+ release from lysosomes. Noncompetitive antagonist. Fluorescent.


Synthetic

Formula: C₃₀H₃₁FN₄O₃
MW: 514,601 g/mol
MDL Number: MFCD02057367
CAS Number: 1354235-96-3

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