8-(4-Chlorophenylthio)-2'-O-methyladenosine-3’,5’-cyclic monophosphate sodium salt ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES AG

ALX480093M001 ALX480093M005
ENZOALX480093M001EA 262.9 EUR
ENZOALX480093M001 ENZOALX480093M005
8-(4-Chlorophenylthio)-2'-O-methyladenosine-3’,5’-cyclic monophosphate sodium salt ≥98% (by HPLC)
8-(4-Chlorophenylthio)-2'-O-methyladenosine-3’,5’-cyclic monophosphate sodium salt

Specific, potent and membrane permeant activator of the Epac cAMP receptor.


Activates Epac1 and Epac2, the guanine nucleotide-exchange factors (GEFs) for the small GTPases Rap1 and Rap2. Does not activate protein kinase A (PKA), neither in vitro nor in vivo and is therefore a valuable tool to specifically discriminate between PKA- and Epac-mediated effects. Since a free 2'-ribose hydroxyl group in cyclic AMP is essential for stimulation of PKA, the methylated structure of 8-CPT-2'-O-Me-cAMP is an extremely poor PKA activator.


Its high lipophilicity allows for good membrane permeability in most biosystems and its increased resistance towards phosphodiesterases prevents rapid hydrolysis.


Hygroscopic and soluble in water, aqueous buffers, DMSO, dimethyl formamide or methanol.

Formula: C₁₇H₁₆ClN₅O₆PS·Na
MW: 507,8 g/mol
Storage Temperature: Freezer
CAS Number: 510774-50-2

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Specification Test Results

Purity (HPLC) ≥98%
Identity Determined by ESI-MS and UV
Purity detail Product is not sterile

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