Gambogic acid ≥95% (by TLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
(Z)-4-((1S,3aR,5S,11R,14aS)-8-Hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-1,2,5,7-tetrahydro-11H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a(4H)-yl)-2-methylbut-2-enoic acid
Gambogic Acid is a natural product isolated from Garcinia Hurburyi. It induces apoptosis in several tumor cell lines including T47D breast cancer cells and MGC-803 human gastric carcinoma cells but not in normal cells. Apoptosis induction proceeds via upregulation of bax and inhibition of bcl-2 expression.The target of gambogic acid has been identified as the transferrin receptor.
- Bcl-2 inhibitor, Bax activator
Yellow-orange solid
Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml)
Formula:
C₃₈H₄₄O₈ MW: 628,762 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD16878985 CAS Number: 2752-65-0 |
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