You Searched For: 3,4,5-Trimethoxyphenol

Catalog Number: (BOSSBS-12922R-CY3)

Supplier: Bioss

Description: The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf’s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase).

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-12922R-CY5)

Supplier: Bioss

Description: The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf’s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase).

UOM: 1 * 100 µl

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Catalog Number: (PRSI55-906)

Supplier: ProSci Inc.

Description: Receptor-regulated class I phosphoinositide 3-kinases (PI3Ks) phosphorylate the membrane lipid phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns(3,4,5)P3, which in turn recruits and activates cytosolic effectors involved in proliferation, survival, or chemotaxis. PIK3R5 is a PI3K regulatory subunit (Brock et al., 2003 [PubMed 12507995]).

UOM: 1 * 400 µl

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Catalog Number: (BOSSBS-2067R-CY5.5)

Supplier: Bioss

Description: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-2067R-CY5)

Supplier: Bioss

Description: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS.

UOM: 1 * 100 µl

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Supplier: Spectrum Chemical

Description: BSE/TSE statement (available upon request)
Allergen statement (available upon request)

Supplier: Roth Carl

Description: D-(+)-Trehalose dihydrate

Supplier: Biotium

Description: X-Gal (5-bromo-4-chloro-3-indolyl-ß-D-galactopyranoside)

MSDS

Catalog Number: (PRSI56-911)

Supplier: ProSci Inc.

Description: FGD2 activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).

UOM: 1 * 400 µl

New Product Sale

Supplier: Thermo Fisher Scientific

Description: N-Octyl-β-D-glucopyranoside 98+%

Certificates

Catalog Number: (MOLEM10742126)

Supplier: Molekula

Description: X-Gal (5-bromo-4-chloro-3-indolyl-ß-D-galactopyranoside)

UOM: 1 * 1 g

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 This is a MarketSource item. Additional charges may apply

Supplier: UPCHURCH SCIENTIFIC

Description: Back pressure regulator assemblies are designed to create incremental back pressures ranging from 5 to 1000 psi (0,3 to 69 bar). These biocompatible and stainless steel back pressure regulator assemblies are available complete with a replaceable, factory pre-set cartridge (except the 5 and 20 psi (0,3 to 1,4 bar versions).

Catalog Number: (SPCMG1165-1KG)

Supplier: Spectrum Chemical

Description: Gluconolactone, USP is used as a slow release acidifier excipient. 

UOM: 1 * 1 kg

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Catalog Number: (MOLEM30473975)

Supplier: Molekula

Description: X-Gal (5-bromo-4-chloro-3-indolyl-ß-D-galactopyranoside)

UOM: 1 * 100 mg

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Catalog Number: (RC-113)

Supplier: G-Biosciences

Description: X-Gal (5-bromo-4-chloro-3-indolyl-ß-D-galactopyranoside)

UOM: 1 * 100 mg

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Catalog Number: (MOLE11322533-5G)

Supplier: Molekula

Description: X-Gal (5-bromo-4-chloro-3-indolyl-ß-D-galactopyranoside)

UOM: 1 * 5 g

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 This is a MarketSource item. Additional charges may apply