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Image Unavailable-BOSSBS-2358R-A488

Anti-FOXA2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-2358R-A488)
Supplier: Bioss
Description: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
UOM: 1 * 100 µl
Image Unavailable-1.17179.0001

Visual colour kits, carbon dioxide, MQuant®

Catalog Number: (1.17179.0001)
Supplier: Merck
Description: Carbon dioxide is an important parameter for the assessment of the surface water quality and of the corrosive behavior of water. The kit is used for water and wastewater treatments following titrimetric method.
UOM: 1 * 1 items

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Image Unavailable-1.11148.0001

Visual colour kits, sulphite, MQuant®, Supelco®

Catalog Number: (1.11148.0001)
Supplier: Merck
Description: MQuant® titrimetric and colorimetric methods.
UOM: 1 * 200 Tests

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Image Unavailable-BOSSBS-2358R-A750

Anti-FOXA2/HNF 3beta Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-2358R-A750)
Supplier: Bioss
Description: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2358R-A680

Anti-FOXA2/HNF 3beta Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-2358R-A680)
Supplier: Bioss
Description: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2358R-CY3

Anti-FOXA2 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-2358R-CY3)
Supplier: Bioss
Description: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
UOM: 1 * 100 µl
Image Unavailable-ENZOBML28330100

Protease inhibitor library, Screen-Well®

Supplier: ENZO LIFE SCIENCES
Description: The Screen-Well™ Protease Inhibitor Library includes 53 known protease inhibitors on a single 96-well plate. Inhibitors are supplied dissolved in DMSO at 10 mM and aliquoted into deep-well plates at either 100 or 500 microliters per well. The library includes inhibitors to a broad range of important proteases and is a convenient and cost-effective way to purchase a panel of protease inhibitors for chemical genomics, assay development, and other applications. It includes inhibitors of: Calpains, TPPII, Neutrophil Elastase, Cathepsins, DPPIV, Caspases, Granzyme B, gamma-Secretase, Furin, MMPs, ACE, Kallikrein, Proteasome, Aminopeptidase B, and many more.

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Image Unavailable-BOSSBS-2358R-A555

Anti-FOXA2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-2358R-A555)
Supplier: Bioss
Description: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8634R-HRP

Anti-FOXA1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-8634R-HRP)
Supplier: Bioss
Description: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
UOM: 1 * 100 µl
Product Image-1.01603.0001

Gram color staining kit modified for Gram staining phenol-free, Sigma-Aldrich®

Catalog Number: (1.01603.0001)
Supplier: Merck
Description: Phenol-free staining kit for the Gram staining method
UOM: 1 * 1 SET

MSDS Certificates


Image Unavailable-1.10307.0500

Reagent Kits for Protein and Fibre Analysis, Supelco®

Catalog Number: (1.10307.0500)
Supplier: Merck
Description: Test kit, Protein (Biuret Method at 546 nm), reagent solution for approx. 250 determinations
UOM: 1 * 500 mL

MSDS Certificates


Product Image-HT102A-1KT

Reticulum Stain Kit acc. to Gordon & Sweets, Sigma-Aldrich®

Catalog Number: (HT102A-1KT)
Supplier: SIGMA ALDRICH MICROSCOPY
Description: The kit is based upon the method of Gordon and Sweets.
UOM: 1 * 1 KIT
Product Image-1.50645.0001

UHPLC columns, Purospher® STAR RP-18 endcapped

Supplier: Merck
Description: Available with optimised 2 μm particulate silica, these UHPLC columns, based on Purospher® STAR RP-18 endcapped, are ideal for ultra-fast applications, where resolution, sensitivity and sample throughput are crucial. They are the first choice for high throughput screening and QC analyses, process monitoring, method development and LC-MS applications. Due to its balanced selectivity, Purospher® STAR RP-18 endcapped UHPLC columns cover almost all demanding separations with tailing-free chromatograms. Purospher® STAR RP-18 endcapped 3 μm columns are recommended for difficult samples where clogging and back pressure present an issue.

MSDS

Image Unavailable-MDT100-1KT

Tissue Marking Dye Kit, Sigma-Aldrich®

Catalog Number: (MDT100-1KT)
Supplier: SIGMA ALDRICH MICROSCOPY
Description: Designed for orientation of excised surgical specimens. This method of permanently marking the margins of tissue specimens is very beneficial to surgeon and pathologists testing for skin cancer.
UOM: 1 * 1 KIT
Image Unavailable-ENZOBMLKI1770005

Fluor-de-Lys® SIRT1 deacetylase substrate

Catalog Number: (ENZOBMLKI1770005)
Supplier: ENZO LIFE SCIENCES
Description: Fluor de Lys®-SIRT1 is a fluorogenic, acetylated peptide substrate for SIRT1 (human Sirtuin 1). Based on residues 379-382 of p53 (Arg-His-Lys-Lys(Ac)), a site of regulatory acetylation by the p300 and CBP acetyltransferases (lysines 381, 382), it was the best substrate for SIRT1 from among a panel of substrates patterned on p53, histone H3, and histone H4 acetylation sites. Fluor de Lys®-SIRT1 is deacetylated by SIRT1 (BML-SE239) at a rate of more then 8-fold that of the acetylated lysine substrate, Fluor de Lys® (Prod. No. BML-KI104; acetylated substrates both at 25 µM, 500 µM NAD+). The Km of Fluor de Lys®-SIRT1 for human recombinant Sirtuin 1 is 108 µM (determined at 37°C, 500 µM NAD+). Must be used in conjunction with Fluor de Lys® Developer II (Prod. No. BML-KI176). Fluorescent signal indicates deacetylation of Lys382. Sufficient for 100-200 assays of human recombinant SIRT1 (1U/well, 50-100 µM substrate).
UOM: 1 * 1 Vial

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Product Image-ENZOENZ450140100

EpiXtract® total histone extraction kit

Catalog Number: (ENZOENZ450140100)
Supplier: ENZO LIFE SCIENCES
Description: Rapid, reliable method to isolate histone proteins in mammalian cells and tissues for histone modification applications.
UOM: 1 * 1 KIT

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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