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Image Unavailable-BOSSBS-2739R-HRP

Anti-PDPK1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-2739R-HRP)
Supplier: Bioss
Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5537R-A555

Anti-PDPK1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-5537R-A555)
Supplier: Bioss
Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3016R-CY7

Anti-MAPK3 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-3016R-CY7)
Supplier: Bioss
Description: p44/42 MAP Kinase(Thr202); ERK (extracellular signal regulated kinase), also known as MAPK (mitogen activated protein kinase) has two closely related isoforms of 44 kDa and 42 kDa, respectively. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth and differentiation as well as the cytoskeleton. ERK1 and ERK2 are phosphorylated within the activation loop on both a Threonine and a Tyrosine residue (within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of ERK1&2.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0559R-CY5.5

Anti-CDK5 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (BOSSBS-0559R-CY5.5)
Supplier: Bioss
Description: CDK5 is serine/threonine kinase involved in synaptic regulation and neuronal development; phosphorylates synaptic protein Pctaire1; regulates acetylcholine receptor expression.CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0559R-CY5

Anti-CDK5 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-0559R-CY5)
Supplier: Bioss
Description: CDK5 is serine/threonine kinase involved in synaptic regulation and neuronal development; phosphorylates synaptic protein Pctaire1; regulates acetylcholine receptor expression.CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.
UOM: 1 * 100 µl
Product Image-BOSSBS-3394R

Anti-MAP2K4 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-3394R)
Supplier: Bioss
Description: This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UOM: 1 * 100 µl
Product Image-0494-25G

(±)-α-Lipoic acid, high purity

Catalog Number: (0494-25G)
Supplier: VWR Chemicals
Description: (±)-α-Lipoic acid, high purity
UOM: 1 * 25 g

MSDS


Image Unavailable-BOSSBS-7850R-A488

Anti-TTK Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-7850R-A488)
Supplier: Bioss
Description: Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7850R-A555

Anti-TTK Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-7850R-A555)
Supplier: Bioss
Description: Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7850R-A647

Anti-TTK Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-7850R-A647)
Supplier: Bioss
Description: Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7908R-HRP

Anti-CLK3 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-7908R-HRP)
Supplier: Bioss
Description: Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines.
UOM: 1 * 100 µl
Image Unavailable-ICNA0210305310

L-Threonine ≥99% allo-free, white powder

Supplier: MP Biomedicals
Description: L-threonine is classified as an essential amino acid. Synthesised from homoserine phosphate by threonine synthase or from acetaldehyde and glycine by serine hydroxy methyltransferase.

Image Unavailable-BOSSBS-5545R-A750

Anti-PDPK1 Ser410 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-5545R-A750)
Supplier: Bioss
Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
UOM: 1 * 100 µl
Image Unavailable-ENZOADIKASST009E

Anti-MAP3K7 Rabbit Polyclonal Antibody

Catalog Number: (ENZOADIKASST009E)
Supplier: ENZO LIFE SCIENCES
Description: TAK1 (TGF-beta-activated kinase-1) is a 65 kDa serine/threonine kinase that is a member of the MAPKKK family. TAK1 is involved in the regulation of transcription by the TGF-beta super family, as its kinase activity is stimulated by TGF-beta and bone morphogenetic protein (BMP).
UOM: 1 * 100 µG
Image Unavailable-BOSSBS-2739R-FITC

Anti-PDPK1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-2739R-FITC)
Supplier: Bioss
Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5545R-FITC

Anti-PDPK1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-5545R-FITC)
Supplier: Bioss
Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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The original product is no longer available. The replacement shown is available.
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