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Product Image-720-2880

Ribbons for Signature® slide printer

Supplier: Primera Technology Europe
Description: Ribbons come in Standard, TC1 or TC2 quality.

Product Image-HERA920091

Storage Racks for Ultra-Low Temperature Freezers

Supplier: Thermo Scientific
Description: <p>Cryobox storage racks makes organising your ultra-low temperature freezer samples easy.</p>

Product Image-129-0501

Mops, Curtain Cleaner™

Supplier: MICRONOVA
Description: A spring loaded, clamp mop that works to clean and sanitize vinyl strip curtains by clamping at the top and sliding down, effectively cleaning both sides at once. Ideal for critical environments, cleanroom support, and industrial applications.

Product Image-MOTIP2S

Inverted microscopes, AE2000

Supplier: MOTIC
Description: AE2000 inverted microscopes are designed for cell culture applications.

Product Image-GAINAZA-67C1-1WH

Removable Blackout Labels for Thermal Transfer Printers

Supplier: GA
Description: These removable labels have a unique opaque design that will obscure all pre-existing information. Can be used to re-identifying slides marked with unclear, erroneous, or incomplete information, but can also be removed or repositioned without leaving behind any residue.

Product Image-309050.

BD Discardit™ II Syringes

Supplier: BD Medical
Description: The BD Discardit™ II two-piece syringe is a single-use medical device intended for injection and aspiration of medical fluids, including both bodily fluids (blood, etc.) and medicines. The lubricant included in the barrel material allows smooth advancement of the plunger, leading to reduced sliding force.

Image Unavailable-BOSSBS-11310R-CY3

Anti-TCTEL1/DYNLT1 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-11310R-CY3)
Supplier: Bioss
Description: Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex transports cellular cargos towards the central region of the cell. Axonemal Dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. Cytoplasmic Dynein is an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. The carboxy terminus of Dynein is important for microtubule-dependent motility and is highly conserved, while the amino terminal regions are more variable. Tctex1 is a cytoplasmic dynein light chain found in a complex with Na+ CP type X?(SCN10A). Tctex1, also designated CW-1 or TCTEL1 is expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Several proteins regulate Dynein activity, including dynactin, LIS1 and NudEL(NudE-like).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3804R-A750

Anti-MSH6 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-3804R-A750)
Supplier: Bioss
Description: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and Recognises single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.
UOM: 1 * 100 µl
Product Image-BOSSBS-0758R

Anti-MSH2 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-0758R)
Supplier: Bioss
Description: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0758R-CY5

Anti-MSH2 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-0758R-CY5)
Supplier: Bioss
Description: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
UOM: 1 * 100 µl
Image Unavailable-OPTKIM3GLASS

Glass Inserts for IM3 Microscopes

Catalog Number: (OPTKIM3GLASS)
Supplier: OPTIKA
Description: Inverted microscopes are useful for observing living cells or organisms at the bottom of a large container (e.g., a tissue culture flask) under more natural conditions than on a glass slide, as it occurs with a conventional microscope. IM-3 series is engineered and designed to be your ideal solution for fast and reliable routine inspections, with the exclusive, state-of-the-art X-LED8 illumination system.
UOM: 1 * 1 items
Product Image-13356770.

VWR® Q Path® Labofix Cytology Fixative

Supplier: VWR Chemicals
Description: Q Path Labofix is a spray cytology fixative able to fix and store the cellular elements from gynaecological and non gynaecological smears after spreading them out on a glass slide.

MSDS Certificates

Product Image-631-0014

Laboratory marker

Catalog Number: (631-0014)
Supplier: MARIENFELD
Description: Permanent marker for indelibly labelling microscope slides and embedding cassettes with a high contrast black ink. Ultra-fine tip. These laboratory markers do not dry out and have a long lifetime.
UOM: 1 * 1 items
Image Unavailable-3882.0500

J.T.Baker®, Mounting Medium, High, Histo Grade

Catalog Number: (3882.0500)
Supplier: Avantor
Description: Mounting medium for coverslipping of slides.
UOM: 1 * 500 mL
Product Image-SCOT233160003

Staining jars, DURAN®

Catalog Number: (SCOT233160003)
Supplier: DWK Life Sciences
Description: Soda-lime glass.
UOM: 1 * 10 items
Product Image-181-0176

Fluid aspiration systems, biovac 106

Supplier: Welch by Gardner Denver
Description: With the biovac 106, nonflammable fluids can be removed easily and very precisely from slides, Petri dishes, cell culture containers, etc, by using different pipettes or glass tips and Pasteur pipettes which can be easily connected to the handvac pipette. The biovac 106 is switched on and off directly at the device or via the optionally available foot switch.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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